The Journey of Data Within a Global Data Sharing Initiative: A Federated 3-Layer Data Analysis Pipeline to Scale Up Multiple Sclerosis Research

Autor: Ashkan Pirmani, Edward De Brouwer, Lotte Geys, Tina Parciak, Yves Moreau, Liesbet M Peeters

Publikováno v: JMIR Medical Informatics, Vol 11, p e48030 (2023)

BackgroundInvestigating low-prevalence diseases such as multiple sclerosis is challenging because of the rather small number of individuals affected by this disease and the scattering of real-world data across numerous data sources. These obstacles i

Externí odkaz: https://doaj.org/article/9fa2536138e84651a25c49c905bfebf4

Machine learning analysis of motor evoked potential time series to predict disability progression in multiple sclerosis

Autor: Jan Yperman, Thijs Becker, Dirk Valkenborg, Veronica Popescu, Niels Hellings, Bart Van Wijmeersch, Liesbet M. Peeters

Publikováno v: BMC Neurology, Vol 20, Iss 1, Pp 1-15 (2020)

Abstract Background Evoked potentials (EPs) are a measure of the conductivity of the central nervous system. They are used to monitor disease progression of multiple sclerosis patients. Previous studies only extracted a few variables from the EPs, wh

Externí odkaz: https://doaj.org/article/ec5d625fdc3b4605b8d29bd6b2bc5139

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation

Autor: Marjan Vanheusden, Bieke Broux, Suzanne P. M. Welten, Liesbet M. Peeters, Eleni Panagioti, Bart Van Wijmeersch, Veerle Somers, Piet Stinissen, Ramon Arens, Niels Hellings

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4+CD28null T cells are only present in CMV seropositive donors and that CMV-specific Imm

Externí odkaz: https://doaj.org/article/3fd87ea4885746a9880b7294e7de70e8

Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis

Autor: Georgina Arrambide, Ingrid van der Mei, Raed Alroughani, Lars Forsberg, Rodden M. Middleton, Guilherme Sciascia do Olival, Nikola Lazovski, Rumen Ivanov, Alexander Stahmann, Tomas Kalincik, Helmut Butzkueven, Richard S. Nicholas, J. Hillert, Alice Estavo Dias, Edward De Brouwer, Amber Salter, Serkan Ozakbas, Nupur Nag, Doralina Guimarães Brum, Alexander Fidao, Anna Zabalza, Yves Moreau, Ricardo Alonso, Anneke Van Der Walt, Nick Rijke, Lotte Geys, Anibal Chertcoff, Arnfin Bergmann, Robert N. McBurney, Clare Walton, Anna Glaser, Tina Parciak, Gilles Edan, Clément Gautrais, Ashkan Pirmani, Maria Fernanda Mendes, Juan Ignacio Rojas, Melinda Magyari, Liesbet M. Peeters, Robert J. Fox, Hollie Schmidt, Amin Ardeshirdavanai, Steve Simpson-Yap, Stefan Braune, Giancarlo Comi, Johana Bauer, Tim Spelman

Publikováno v: Scientia
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Neurology
article-version (Version of Record) 3

Made available in DSpace on 2022-04-28T19:46:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-09 Background and ObjectivesPeople with multiple sclerosis MS are a vulnerable group for severe coronavirus disease 2019 COVID-19, particularly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbb50404f289c1a781c29206cd86560
https://doi.org/10.1212/wnl.0000000000012753

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression

Autor: Liesbet M. Peeters, Marjan Vanheusden, Veerle Somers, Bart Van Wijmeersch, Piet Stinissen, Bieke Broux, Niels Hellings

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Multiple sclerosis (MS) is the leading cause of chronic neurological disability in young adults. The clinical disease course of MS varies greatly between individuals, with some patients progressing much more rapidly than others, making prognosis almo

Externí odkaz: https://doaj.org/article/49b1a6be31d34f458d780026ad10cb56