Exogenous APN protects normal tissues from radiation-induced oxidative damage and fibrosis in mice and prostate cancer patients with higher levels of APN have less radiation-induced toxicities.

Autor: McDowell JA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Kosmacek EA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Baine MJ; Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Adebisi O; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Zheng C; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Bierman MM; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Myers MS; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Chatterjee A; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Liermann-Wooldrik KT; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Lim A; College of Nursing, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Dickinson KA; College of Nursing, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Oberley-Deegan RE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: becky.deegan@unmc.edu.

Publikováno v: Redox biology [Redox Biol] 2024 Jul; Vol. 73, pp. 103219. Date of Electronic Publication: 2024 May 31.