Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Liente Wei"'
Autor:
Bridget Butler, Thomas M. Jacks, Roy G. Smith, Kang Cheng, Patrick P. Pollard, Wanda W.-S. Chan, Meng-Hsin Chen, Arthur A. Patchett, Liente Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1261-1266
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replace
Autor:
Arthur A. Patchett, Zhijian Lu, Bridget Butler, Thomas M. Jacks, Liente Wei, Gerard J. Hickey, Kang Cheng, Wanda W.-S. Chan, Klaus D. Schleim, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3657-3659
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jac
Autor:
Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally a
Autor:
Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:663-668
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth
Autor:
Arthur A. Patchett, Mark G. Steiner, Bridget Butler, Wanda W.-S. Chan, Liente Wei, Kang Cheng, Meng-Hsin Chen, Roy G. Smith, Thomas M. Jacks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2163-2168
A series of spiroindane growth hormone secretagogues that vary in their amino side chains is reported. Variations in these side chains markedly affect growth hormone release in vitro and in vivo . The best side chain in this series of secretagogues i
Autor:
Kang Cheng, James R. Tata, Khaled J. Barakat, Roy G. Smith, Liente Wei, B. Butler, Johnston David B R, Wanda W.-S. Chan, Arthur A. Patchett, Meng-Hsin Chen, Ravi P. Nargund, Thomas M. Jacks, Gerard J. Hickey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1731-1736
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with sign
Publikováno v:
Biochemical and Biophysical Research Communications. 197:1396-1401
Pituitary adenylate cyclase activating polypeptide (PACAP38) stimulated growth hormone release as well as cAMP accumulation in a static rat primary pituitary cell culture in a dose-dependent manner with EC50 values of 1.9 ± 0.4 nM (n=13) and 0.9 ±
Publikováno v:
Hormone Research. 40:109-115
Direct screening of preselected compounds in a rat primary pituitary cell culture assay, followed by chemical modification of selected pharmacophores led to the identification of a novel non-peptidyl class of GH secretagogues (substituted benzolactam
Autor:
Meng-Hsin Chen, Thomas M. Jacks, Liente Wei, Roy G. Smith, Arthur A. Patchett, Kang Cheng, Wanda W.-S. Chan, Bridget Butler, Patrick P. Pollard
Publikováno v:
ChemInform. 30
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replace
Autor:
David J. Morris, Charles O. Watlington, Tammy J. Conca, Syed A. Latif, Cedric H.L. Shackleton, David N. Kirk, Liente Wei, Harold Toms
Publikováno v:
Steroids. 55:482-486
Incubation of aldoslerone with confluent layers of A6 (toad kidney) cells leads to its hydroxylation at the 6β-position. 6β-Hydroxyaldosterone is the major metabolite when the incubation is carried out at pH 6.8, whereas the product comprises dβ-h