Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development.

Autor: Ceroni F; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Cicekdal MB; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Holt R; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK., Sorokina E; Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA., Chassaing N; Centre de Référence des Affections Rares en Génétique Ophtalmologique CARGO, Site Constitutif, CHU Toulouse, Toulouse, France.; Service de Génétique Médicale, Hôpital Purpan, CHU de Toulouse, Toulouse, France., Clokie S; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK., Naert T; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Institute of Anatomy, University of Zurich, Zurich, Switzerland.; Zurich Kidney Center, University of Zurich, Zurich, Switzerland., Talbot LV; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK., Muheisen S; Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA., Bax DA; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK., Kesim Y; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.; Centre for Human Genetics, University of Oxford, Old Road Campus, Oxford, UK.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kivuva EC; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Vincent-Delorme C; Service de Génétique Clinique Guy Fontaine, Hôpital Jeanne de Flandre, Lille, France., Lienkamp SS; Institute of Anatomy, University of Zurich, Zurich, Switzerland.; Zurich Kidney Center, University of Zurich, Zurich, Switzerland., Plaisancié J; Centre de Référence des Affections Rares en Génétique Ophtalmologique CARGO, Site Constitutif, CHU Toulouse, Toulouse, France.; Service de Génétique Médicale, Hôpital Purpan, CHU de Toulouse, Toulouse, France.; Centre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS, UPS, Toulouse, France., De Baere E; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Calvas P; Centre de Référence des Affections Rares en Génétique Ophtalmologique CARGO, Site Constitutif, CHU Toulouse, Toulouse, France.; Service de Génétique Médicale, Hôpital Purpan, CHU de Toulouse, Toulouse, France., Vleminckx K; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. kris.vleminckx@irc.ugent.be., Semina EV; Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA. esemina@mcw.edu., Ragge NK; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK. nragge@brookes.ac.uk.; West Midlands Regional Clinical Genetics Service, Birmingham Women's and Children's NHS Foundation Trust and Birmingham Health Partners, Birmingham, UK. nragge@brookes.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 26; Vol. 15 (1), pp. 9245. Date of Electronic Publication: 2024 Oct 26.

Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples.

Autor: Vladimirov N; Brain Research Institute, University of Zurich, Zurich, Switzerland. vladimirov@hifo.uzh.ch.; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich, Switzerland. vladimirov@hifo.uzh.ch.; Center for Microscopy and Image Analysis (ZMB), University of Zurich, Zurich, Switzerland. vladimirov@hifo.uzh.ch., Voigt FF; Brain Research Institute, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Naert T; Institute of Anatomy and Zurich Kidney Center (ZKC), University of Zurich, Zurich, Switzerland., Araujo GR; Department of Physics, University of Zurich, Zurich, Switzerland., Cai R; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Department of Biology, Stanford University, Stanford, CA, USA., Reuss AM; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Zhao S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Schmid P; Institute of Anatomy and Zurich Kidney Center (ZKC), University of Zurich, Zurich, Switzerland., Hildebrand S; Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, The Netherlands., Schaettin M; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Groos D; Brain Research Institute, University of Zurich, Zurich, Switzerland., Mateos JM; Center for Microscopy and Image Analysis (ZMB), University of Zurich, Zurich, Switzerland., Bethge P; Brain Research Institute, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland., Yamamoto T; Institute of Anatomy and Zurich Kidney Center (ZKC), University of Zurich, Zurich, Switzerland., Aerne V; Department of Physics, University of Zurich, Zurich, Switzerland., Roebroeck A; Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, The Netherlands., Ertürk A; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany., Aguzzi A; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Ziegler U; Center for Microscopy and Image Analysis (ZMB), University of Zurich, Zurich, Switzerland., Stoeckli E; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Baudis L; Department of Physics, University of Zurich, Zurich, Switzerland., Lienkamp SS; Institute of Anatomy and Zurich Kidney Center (ZKC), University of Zurich, Zurich, Switzerland., Helmchen F; Brain Research Institute, University of Zurich, Zurich, Switzerland. helmchen@hifo.uzh.ch.; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich, Switzerland. helmchen@hifo.uzh.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland. helmchen@hifo.uzh.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 27; Vol. 15 (1), pp. 2679. Date of Electronic Publication: 2024 Mar 27.

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope.

Autor: Voigt FF; Brain Research Institute, University of Zurich, Zurich, Switzerland. fvoigt@fas.harvard.edu.; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland. fvoigt@fas.harvard.edu.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. fvoigt@fas.harvard.edu., Reuss AM; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Naert T; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Hildebrand S; Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, the Netherlands., Schaettin M; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Hotz AL; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Whitehead L; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Bahl A; Centre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, Germany., Neuhauss SCF; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Roebroeck A; Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, the Netherlands., Stoeckli ET; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zürich, Zurich, Switzerland., Lienkamp SS; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Aguzzi A; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Helmchen F; Brain Research Institute, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zürich, Zurich, Switzerland.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Jan; Vol. 42 (1), pp. 65-71. Date of Electronic Publication: 2023 Mar 30.

A novel role for the chloride intracellular channel protein Clic5 in ciliary function.

Autor: Ott E; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany., Hoff S; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany., Indorf L; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany., Ditengou FA; Bio Imaging Core Light Microscopy (BiMiC), Medical Faculty-Institute for Disease Modeling and Targeted Medicine (IMITATE), 79106, Freiburg, Germany., Müller J; Limbach Genetics, Medizinische Genetik Mainz, 55128, Mainz, Germany., Renschler G; Limbach Genetics, Medizinische Genetik Mainz, 55128, Mainz, Germany., Lienkamp SS; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), 79104, Freiburg, Germany., Kramer-Zucker A; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany., Bergmann C; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany.; Limbach Genetics, Medizinische Genetik Mainz, 55128, Mainz, Germany., Epting D; Department of Medicine IV, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany. daniel.epting@uniklinik-freiburg.de.

Publikováno v: Scientific reports [Sci Rep] 2023 Oct 17; Vol. 13 (1), pp. 17647. Date of Electronic Publication: 2023 Oct 17.

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.

Autor: Grand K; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Stoltz M; The University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Rizzo L; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Röck R; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Kaminski MM; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Salinas G; Berlin Institute of Health, Berlin, Germany., Getwan M; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Naert T; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Pichler R; The University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lienkamp SS; Institute of Anatomy, University of Zurich, Zurich, Switzerland.; The University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2023 Mar 01; Vol. 34 (3), pp. 412-432. Date of Electronic Publication: 2022 Dec 15.