Výsledky vyhledávání - "Lienhard Lessel"

Akademický článek

Refractory and relapsed paediatric ACC in the MET studies – A challenging situation necessitating novel diagnostic and therapeutic concepts

Autor: Michaela Kuhlen, Marina Kunstreich, Lienhard Lessel, Stefan A. Wudy, Paul-Martin Holterhus, Christian Vokuhl, Eva Juettner, Christoph Roecken, Guido Seitz, Christoph Slavetinsky, Jörg Fuchs, Denis M. Schewe, Rainer Claus, Pascal D. Johann, Michael C. Frühwald, Peter Vorwerk, Antje Redlich

Publikováno v: EJC Paediatric Oncology, Vol 1, Iss , Pp 100015- (2023)

Background: Paediatric adrenocortical carcinomas (ACC) are highly aggressive malignancies with a dismal prognosis in advanced and metastatic diseases. Little is known about outcome of patients with refractory and relapsed (r/r) disease. Procedure: Na

Externí odkaz: https://doaj.org/article/87befb459f374e449313ef4fba15ab29

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Key factors for effective mitotane therapy in children with adrenocortical carcinoma

Autor: Michaela Kuhlen, Pascal Mier, Marina Kunstreich, Lienhard Lessel, Dominik Schneider, Ines Brecht, Denis M Schewe, Michael C Frühwald, Peter Vorwerk, Antje Redlich

Publikováno v: Endocrine-related cancer. 29(9)

Adjuvant treatment with mitotane and chemotherapy is recommended for paediatric advanced and metastatic adrenocortical carcinoma (ACC). Yet, questions on the indication, dosage, and length of therapy are unanswered. Data from the German Paediatric On

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebc3b8162ef38b54cb7e89b0694f038
https://pubmed.ncbi.nlm.nih.gov/35900840

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Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process

Autor: Cihan Papan, Katharina Reifenrath, Katharina Last, Andishe Attarbaschi, Norbert Graf, Andreas H. Groll, Johannes Hübner, Hans-Jürgen Laws, Thomas Lehrnbecher, Johannes G. Liese, Luise Martin, Tobias Tenenbaum, Simon Vieth, Ulrich von Both, Gudrun Wagenpfeil, Stefan Weichert, Markus Hufnagel, Arne Simon, Jan Baier, Stefan Balzer, Ümmügül Behr, Benedikt Bernbeck, Karin Beutel, Claudia Blattmann, Konrad Bochennek, Holger Cario, Angelika Eggert, Karoline Ehlert, Simone Göpner, Udo Kontny, Dieter Körholz, Christof Kramm, Melchior Lauten, Lienhard Lessel, Christin Linderkamp, Stephan Lobitz, Volker Maas, Rainer Misgeld, Urs Mücke, Jennifer Neubert, Lisa Nonnenmacher, Manon Queudeville, Antje Redlich, Martina Rodehüser, Sarah Schober, Meinolf Siepermann, Thorsten Simon, Hadi Souliman, Martina Stiefel, Verena Wiegering, Beate Winkler

Publikováno v: The Lancet Regional Health - Europe. 28:100599

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8011a029d374fb6f4e6e93e4986b21a
https://doi.org/10.1016/j.lanepe.2023.100599

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SMARCB1-deficient and SMARCA4-deficient malignant brain tumors with complex copy number alterations and TP53 mutations may represent the first clinical manifestation of Li-Fraumeni syndrome

Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant central nervous system tumor predominantly affecting infants. Mutations of SMARCB1 or (rarely) SMARCA4 causing loss of nuclear SMARCB1 or SMARCA4 protein expression are characteristic features,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea3e29193baaa69a9da863682580409
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/95197

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Outcome for Pediatric Adreno-Cortical Tumors Is Best Predicted by the COG Stage and Five-Item Microscopic Score—Report from the German MET Studies

Autor: Michaela Kuhlen, Marina Kunstreich, Stefan A. Wudy, Paul-Martin Holterhus, Lienhard Lessel, Dominik T. Schneider, Ines B. Brecht, Denis M. Schewe, Guido Seitz, Christoph Roecken, Christian Vokuhl, Pascal D. Johann, Michael C. Frühwald, Peter Vorwerk, Antje Redlich

Publikováno v: Cancers; Volume 15; Issue 1; Pages: 225

Background: Adrenocortical tumors (ACTs) encompassing the adrenocortical adenoma (ACA), carcinoma (ACC), and tumors of undetermined malignant potential (ACx) are rare endocrine neoplasms with a poor prognosis. We report on pediatric ACT patients regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc934b5ef259e92e70113221a9d07a
https://doi.org/10.3390/cancers15010225

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Age, American Thyroid Association Risk Group, and Response to Therapy Are Prognostic Factors in Children With Differentiated Thyroid Cancer

Autor: Kerstin Lorenz, Michael C. Frühwald, Peter Vorwerk, Kurt Werner Schmid, Antje Redlich, Tilman R Rohrer, Lienhard Lessel, Michaela Kuhlen, Markus Luster

Publikováno v: The Journal of clinical endocrinology and metabolism. 107(1)

Context Against the background of increasing incidence, pediatric differentiated thyroid carcinoma (DTC) frequently presents with advanced disease and high recurrence rates while prognosis remains excellent. Background We investigated the use of a pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549e200dba2ae151ae7f6e59e648de6d
https://pubmed.ncbi.nlm.nih.gov/34610121

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ATRT-08. SMARCB1- and SMARCA4-deficient malignant brain tumors with complex copy number alterations andTP53 mutations may represent the first clinical manifestation of Li-Fraumeni syndrome

Publikováno v: Neuro-Oncology. 24:i4-i4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2d17959970d1750a8aadf699afbb6fb
https://doi.org/10.1093/neuonc/noac079.007

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Pseudohypoxic pheochromocytomas and paragangliomas dominate in children

Autor: Michael C. Frühwald, Peter Vorwerk, Antje Redlich, Michaela Kuhlen, Christina Pamporaki, Lienhard Lessel

Objective Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that are associated with cancer predisposition syndromes in up to 80% of affected children. PPGLs can be divided into molecularly defined groups with comparable pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e122b1a99f31eba01ada5d5904d50cc

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Multiple endocrine neoplasia type 2B: Frequency of physical stigmata—Results of the GPOH‐MET registry

Autor: Antje Redlich, Artemis Petrou, Pascal Mier, Peter Vorwerk, Lienhard Lessel

Publikováno v: Pediatric Blood & Cancer. 67

BACKGROUND Multiple endocrine neoplasia (MEN) 2B is characterized by early development of aggressive medullary thyroid carcinoma (MTC), visible physical stigmata, and associated symptoms. In most cases, de novo mutations are revealed. There are premo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4703c2120157e352f9d4f2bf600f5d5e
https://doi.org/10.1002/pbc.28056

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