Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Lieneke Pool"'
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Akademický článek
Tolerogenic dendritic cells generated in vitro using a novel protocol mimicking mucosal tolerance mechanisms represent a potential therapeutic cell platform for induction of immune tolerance
Autor: Gillian Dao Nyesiga, Lieneke Pool, Pavlos C. Englezou, Terese Hylander, Lars Ohlsson, Daniel Appelgren, Anette Sundstedt, Kristina Tillerkvist, Hanne R. Romedahl, Maria Wigren
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and
Externí odkaz: https://doaj.org/article/f2c2984fc5da4eb8b7fc390b4c372a1e
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2
Deletion of IRF4 in Dendritic Cells Leads to Delayed Onset of T Cell-Dependent Colitis
Autor: William W. Agace, Aymeric Rivollier, Lieneke Pool
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 204(4)
Classical dendritic cells (cDC) can be classified into two major subsets: Irf8-dependent cDC1 and Irf4-expressing cDC2. Although these subsets play distinct roles in intestinal immune homeostasis, their functions in T cell–driven colitis remain unk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b32c59cf05cc504888cc120ddbf279
https://pubmed.ncbi.nlm.nih.gov/31900340
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3
IL-18Rα-deficient CD4+T cells induce intestinal inflammation in the CD45RBhitransfer model of colitis despite impaired innate responsiveness
Autor: Lieneke Pool, Karin Hägerbrand, Petra Holmkvist, Aymeric Rivollier, William W. Agace
Publikováno v: Holmkvist, P, Pool, L, Hägerbrand, K, Agace, W W & Rivollier, A M C 2016, ' IL-18Rα-deficient CD4+T cells induce intestinal inflammation in the CD45RBhitransfer model of colitis despite impaired innate responsiveness ', European Journal of Immunology, vol. 46, no. 6, pp. 1371-1382 . https://doi.org/10.1002/eji.201545957
IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4(+) T-cell function remains unclear. Here we show that murine intestinal CD4(+) T cells express high levels of IL-18Rα and provide evi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38470d273c4f4fafd948b77e0704d2a8
https://doi.org/10.1002/eji.201545957
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4
IRF8 dependent classical dendritic cells are essential for intestinal T cell homeostasis
Autor: Luda, K., Thorsten Joeris, Persson, E. K., Aymeric Marie Christian Rivollier, Demiri, M., Katarzyna Maria Sitnik, Lieneke Pool, Holm, J. B., Melo-Gonzalez, F., Richter, L., Lambrecht, B. N., Karsten Kristiansen, Travis, M. A., Svensson-Frej, M., Kotarsky, K., william Agace
Publikováno v: Luda, K, Joeris, T, Persson, E K, Rivollier, A M C, Demiri, M, Sitnik, K M, Pool, L, Holm, J B, Melo-Gonzalez, F, Richter, L, Lambrecht, B N, Kristiansen, K, Travis, M A, Svensson-Frej, M, Kotarsky, K & Agace, W W 2016, ' IRF8 dependent classical dendritic cells are essential for intestinal T cell homeostasis ', European Journal of Immunology, vol. 46, no. Suppl. 1, pp. 946-946 .
Technical University of Denmark Orbit
The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 dependent DCs have reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b3a900f86a8cd757201720450cc35706
https://orbit.dtu.dk/en/publications/27dfa7ab-c74a-4e5c-9a4d-ea406d59d2dd
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5
IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis
Autor: Katarzyna M. Sitnik, Katarzyna Müller Luda, Mimoza Demiri, Thorsten Joeris, Bart N. Lambrecht, Marcus Svensson-Frej, Knut Kotarsky, Mark A. Travis, Emma Persson, William W. Agace, Lisa Richter, Lieneke Pool, Aymeric Rivollier, Jacob Bak Holm, Karsten Kristiansen, Felipe Melo-Gonzalez
Publikováno v: Luda, K M, Joeris, T, Persson, E K, Rivollier, A M C, Demiri, M, Sitnik, K M, Pool, L, Holm, J B, Melo-Gonzalez, F, Richter, L, Lambrecht, B N, Kristiansen, K, Travis, M A, Svensson-Frej, M, Kotarsky, K & Agace, W W 2016, ' IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis ', Immunity, vol. 44, no. 4, pp. 860-874 . https://doi.org/10.1016/j.immuni.2016.02.008
The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614edf58e4a1e582956f79d21210fbe8
https://orbit.dtu.dk/en/publications/37b40a13-cf47-42c0-b951-6c51ef493f0e
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7
Retinoic Acid Modulates the Early Expansion and Differentiation of CD4(+) T Cells During the Development of Intestinal Inflammation
Autor: Aymeric Marie Christian Rivollier, Lieneke Pool, Kerstin Wendland, william Agace
Publikováno v: Technical University of Denmark Orbit
Rivollier, A M C, Pool, L, Wendland, K & Agace, W W 2014, ' Retinoic Acid Modulates the Early Expansion and Differentiation of CD4(+) T Cells During the Development of Intestinal Inflammation ', Scandinavian Journal of Immunology, vol. 79, no. 6, pp. 440-440 .
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0600a549e66fca68b4a3c0d100d061d0
https://orbit.dtu.dk/en/publications/27be8e57-6075-4859-8807-8d0f5f74304c
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8
Retinoic acid signalling is required for the efficient differentiation of CD4+ T cells into pathogenic effector cells during the development of intestinal inflammation
Autor: Aymeric Marie Christian Rivollier, Lieneke Pool, Ulrika Frising, Kerstin Wendland, william Agace
Publikováno v: Technical University of Denmark Orbit
Rivollier, A M C, Pool, L, Frising, U, Wendland, K & Agace, W W 2015, ' Retinoic acid signalling is required for the efficient differentiation of CD4+ T cells into pathogenic effector cells during the development of intestinal inflammation ', 17th International Congress of Mucosal Immunology, Berlin, Germany, 14/07/2015-18/07/2015 .
Epidemiological studies of vitamin A-deficient populations have illustrated the importance of the vitamin A metabolite retinoic acid (RA) in mucosal immune responses. However, RA seems to be a double-edge sword in CD4+ T cell biology. While it sustai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5fd087af22bd1e926b695e9759279848
https://orbit.dtu.dk/en/publications/967c6d30-9eed-433f-8b3d-4837acfc28c8
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10
Involvement of IRF4 dependent dendritic cells in T cell dependent colitis
Autor: Lieneke Pool, Aymeric Marie Christian Rivollier, william Agace
Publikováno v: Technical University of Denmark Orbit
Pool, L, Rivollier, A M C & Agace, W W 2015, ' Involvement of IRF4 dependent dendritic cells in T cell dependent colitis ', Keystone Symposia on Molecular and Cellular Biology-Dendritic Cells and Macrophages Reunited, Montreal, Canada, 08/03/2015-13/03/2015 .
Pool, L, Rivollier, A M C & Agace, W W 2015, ' Involvement of IRF4 dependent dendritic cells in T cell dependent colitis ', 17th International Congress of Mucosal Immunology, Berlin, Germany, 14/07/2015-18/07/2015 .
Inflammatory Bowel Disease (IBD) is a chronic non-curable inflammatory disease of the intestine that affects as many as 1.4 million persons in the United States and 2.2 million persons in Europe. IBD results from abnormal immune response to bacterial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::008b1274e2f570c02b9444ea86622a2e
https://orbit.dtu.dk/en/publications/15a5d9b3-9c91-4b73-b212-3182ff09c122
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