Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lien-Szu Wu"'
Autor:
Shih-Ling Huang, Lien-Szu Wu, Min Lee, Chin-Wen Chang, Wei-Cheng Cheng, Yu-Sheng Fang, Yun-Ru Chen, Pei-Lin Cheng, Che-Kun James Shen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral sclerosis (ALS) patients are characterized by the mis-metaboli
Externí odkaz:
https://doaj.org/article/71b5482bb0dd4b42859ddd6b87c2f8a7
Autor:
Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. James Shen
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-31 (2019)
Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral sclerosis (ALS) and frontotemp
Externí odkaz:
https://doaj.org/article/7a2197f0e5474d4a8e04647dddfeea46
Physiological Function and Pathological Dysfunction of TDP-43 in Mammalian Spinal Cord Motor Neurons
Autor:
Lien-Szu Wu, 武蓮絲
101
TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range of neurodegenerative diseases
TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range of neurodegenerative diseases
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/44785428921473418838
Autor:
Lien-Szu Wu, 武蓮絲
95
In mammalian nervous system, the spatiotemporal control of mRNA translation plays an important role in synaptic development and plasticity. TAR DNA / RNA binding protein (TDP-43), a highly conserved heterogeneous nuclear ribonucleo-protein, h
In mammalian nervous system, the spatiotemporal control of mRNA translation plays an important role in synaptic development and plasticity. TAR DNA / RNA binding protein (TDP-43), a highly conserved heterogeneous nuclear ribonucleo-protein, h
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/18470773836983743542
Autor:
Shih-Ling Huang, Lien-Szu Wu, Lee, Min, Chin-Wen Chang, Cheng, Wei-Cheng, Fang, Yu-Sheng, Yun-Ru Chen, Cheng, Pei-Lin, Che-Kun Shen
Additional file 6: Figure S6. Decreased of p62 protein level and enhanced of the proteasome activities in the spinal cord, but not the forebrain, of symptomatic N390D/+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143fc7db57d826951494a86ed41ccc5e
Autor:
Shih Ling Huang, Pei Lin Cheng, Min Lee, Lien Szu Wu, Che Kun James Shen, Yun-Ru Chen, Yu Sheng Fang, Wei Cheng Cheng, Chin Wen Chang
Publikováno v:
Acta Neuropathologica Communications
Acta neuropathologica communications, vol 8, iss 1
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Acta neuropathologica communications, vol 8, iss 1
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral sclerosis (ALS) patients are characterized by the mis-metabolism of the
Autor:
Yu Hsiang Tseng, Trees-Juen Chuang, Wei Cheng Cheng, Che-Kun Shen, Lien Szu Wu, Yi-Chi Wang, Chia Ying Chen, Ming Che Wu
Publikováno v:
Acta neuropathologica communications, vol 7, iss 1
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-31 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-31 (2019)
Acta Neuropathologica Communications
TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral sclerosis (ALS) and frontotemporal loba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13e51b716d3ab09476b38f14df42153
https://escholarship.org/uc/item/1126x0dr
https://escholarship.org/uc/item/1126x0dr
Autor:
Lien-Szu Wu, Cheng, Wei-Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. Shen
Figure S1. Altered activity of daily living (ADL) of TDP-43 cKO mice. Figure S2. Immunohistochemistry staining of brain slices. Figure S3. Persisting reactive astrocytosis in TDP-43 cKO mouse forebrain. Figure S4. Electrophysiology measurements. Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6bb5bb90dd8836cdbb8fab8c0272e0
Autor:
Lien-Szu Wu, Cheng, Wei-Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. Shen
Table S2. Changes of the mRNA levels of social behaviour-related genes in the neocortex of TDP-43 cKO mice relative to Ctrl mice. (PDF 72 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde43bd2788493430c85fe40f04c720
Autor:
Lien-Szu Wu, Cheng, Wei-Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. Shen
Table S1. List of the chromosome numbers, donor positions, acceptors positions and gene names of the transcripts from which the individual circularRNAs change in the neocortex of 3- and 12-month-old TDP-43 cKO mice, but not Ctrl mice are listed. (PDF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d574e3bdcd4f5e5021b58711812e023