Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lien D Nguyen"'
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
Autor:
Lien D Nguyen, Barbara E Ehrlich
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-17 (2020)
Abstract Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including imprecise diagnosis criteria, multiple confounding fac
Externí odkaz:
https://doaj.org/article/4554494c24544e7e82d958a843d63a64
Autor:
Lien D. Nguyen, Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Rosalia Rabinovsky, Christina R. Muratore, Jonathan M. S. Stricker, Colin Hortman, Tracy L. Young-Pearse, Stephen J. Haggarty, Anna M. Krichevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies
Externí odkaz:
https://doaj.org/article/b8a8e54f65f640bfad7b904c07567fde
Autor:
Lien D. Nguyen, Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Rosalia Rabinovsky, Christina R. Muratore, Jonathan M. S. Stricker, Colin Hortman, Tracy L. Young-Pearse, Stephen J. Haggarty, Anna M. Krichevsky
SUMMARYMicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc8ab5e5cd01989c43cc4a62ce97ab0
https://doi.org/10.1101/2022.11.01.514550
https://doi.org/10.1101/2022.11.01.514550
Autor:
Winston Tan, Joseph Santos-Sacchi, Denise Giuvelis, Edward J. Bilsky, Barbara E. Ehrlich, Luca G. Nolte, Lien D. Nguyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ababbf427ad7cc4149821fbb89c2930
https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
Publikováno v:
J Biol Chem
Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are endoplasmic reticulum–localized channels that mediate Ca(2+) release from the endoplasmic reticulum into the cytoplasm. We previously reported that an EF-hand Ca(2+)-binding protein, neuronal cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1963cd3a36ce11572868f4e4cb8dc8d2
https://doi.org/10.1074/jbc.ra119.009736
https://doi.org/10.1074/jbc.ra119.009736
Publikováno v:
FASEB J
Calcium (Ca2+) signaling is critical for neuronal functioning and requires the concerted interplay of numerous Ca2+-binding proteins, including neuronal calcium sensor 1 (NCS1). Although an important role of NCS1 in neuronal processes and in neurodev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7eee4b4117f9c6868d71f312941890
https://europepmc.org/articles/PMC8462996/
https://europepmc.org/articles/PMC8462996/
Publikováno v:
Cell Calcium. 104:102572
Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa1ca18c422352a516a8ca9814d3916
https://doi.org/10.1016/j.ceca.2022.102572
https://doi.org/10.1016/j.ceca.2022.102572
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain unclear. We previously est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a641897aa4864b68d0f08f1550e15af
https://pubmed.ncbi.nlm.nih.gov/34174909
https://pubmed.ncbi.nlm.nih.gov/34174909
Autor:
Alfredo Arroyo, Tom T. Fischer, Barbara E. Ehrlich, Damien Abreu, Lien D. Nguyen, Fumihiko Urano
Publikováno v:
Proc Natl Acad Sci U S A
Wolfram syndrome is a rare multisystem disease characterized by childhood-onset diabetes mellitus and progressive neurodegeneration. Most cases are attributed to pathogenic variants in a single gene, Wolfram syndrome 1 (WFS1). There currently is no d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1fa649e4e743da5428f99f08804eb0
https://pubmed.ncbi.nlm.nih.gov/32632005
https://pubmed.ncbi.nlm.nih.gov/32632005
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
Autor:
Barbara E. Ehrlich, Lien D. Nguyen
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including imprecise diagnosis criteria, multiple confounding factors, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735cfe45f27c9837568695ff00e84bb6
http://europepmc.org/articles/PMC7278555
http://europepmc.org/articles/PMC7278555