Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Liem H Nguyen"'
Autor:
Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, Hao Zhu
Publikováno v:
eLife, Vol 6 (2017)
Sequencing studies have implicated haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O'Roak et al., 2012), intellectual disability (Deciphering Developmental Disorders
Externí odkaz:
https://doaj.org/article/ed40f28284084f4c913b487a3f35a670
Autor:
Linwei Wu, Liem H Nguyen, Kejin Zhou, T Yvanka de Soysa, Lin Li, Jason B Miller, Jianmin Tian, Joseph Locker, Shuyuan Zhang, Gen Shinoda, Marc T Seligson, Lauren R Zeitels, Asha Acharya, Sam C Wang, Joshua T Mendell, Xiaoshun He, Jinsuke Nishino, Sean J Morrison, Daniel J Siegwart, George Q Daley, Ng Shyh-Chang, Hao Zhu
Publikováno v:
eLife, Vol 4 (2015)
The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive roles at the expense of regeneration. Too littl
Externí odkaz:
https://doaj.org/article/59dfff35532043c7a4356bb1fec531e8
Publikováno v:
SAGE Open Medical Case Reports, Vol 12 (2024)
Re-expansion pulmonary edema is defined as pulmonary edema that occurs when a chronically collapsed lung rapidly re-expands, most commonly following chest tube placement for pneumothorax, re-expansion of severe atelectasis, and evacuation of pleural
Externí odkaz:
https://doaj.org/article/8eb6e8ce682d4f07a06053f1b8ee73c8
Autor:
Shuyuan Zhang, Jeanne Shen, Scott Daigle, Xuxu Sun, Jeon Lee, Liem H. Nguyen, Sam C. Wang, Lin Li, Lan Peng, Jen Chieh Chuang, Shu Xiao, Hao Zhu, Ibrahim Nassour, Xin Luo
Publikováno v:
Gut
ObjectiveARID1A is commonly mutated in pancreatic ductal adenocarcinoma (PDAC), but the functional effects of ARID1A mutations in the pancreas are unclear. Understanding the molecular mechanisms that drive PDAC formation may lead to novel therapies.D
Autor:
Joshua Goodman, Purva Gopal, Yu Zhang, Shuyuan Zhang, Kejin Zhou, Amit G. Singal, Daniel J. Siegwart, Liem H. Nguyen, Lin Li, Adam C. Yopp, Ibrahim Nassour, Hao Zhu, Ho Chou Tu, Alfica Sehgal
Publikováno v:
Gastroenterology. 154:1421-1434
Background & Aims Cytokinesis can fail during normal postnatal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver slows tumor growth without compromising the health of normal hepatocytes.
Autor:
Xin Luo, Lin Li, Purva Gopal, Yu Zhang, Kejin Zhou, Hao Zhu, Alfica Sehgal, Ho-Chou Tu, Liem H. Nguyen, Branden D. Tarlow, Shuyuan Zhang, Daniel J. Siegwart
Publikováno v:
Developmental cell. 47(3)
Summary Most cells in the liver are polyploid, but the functional role of polyploidy is unknown. Polyploidization occurs through cytokinesis failure and endoreduplication around the time of weaning. To interrogate polyploidy while avoiding irreversib
Autor:
Hao Zhu, Jen Chieh Chuang, Shuyuan Zhang, Meng Wu, Zhong Wang, Liem H. Nguyen, Jian Xu, Linwei Wu, Chao Xing, Lin Li, Robert A.J. Signer, Yong Zhao, Thomas Maples, Yi Chun Kuo, Mahsa Sorouri, Xin Liu, Sam C. Wang, Ibrahim Nassour, Cemre Celen, Mohammed Kanchwala, Hanquan Liang, Xuxu Sun
Publikováno v:
Cell Stem Cell. 18:456-466
Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substanti
Autor:
Jason B. Miller, Yunfeng Yan, Kejin Zhou, Daniel J. Siegwart, Petra Kos, Hu Xiong, Liem H. Nguyen, Hao Zhu, Jing Hao, Lin Li, Jonathan T. Minnig
Publikováno v:
Proceedings of the National Academy of Sciences. 113:520-525
RNA-based cancer therapies are hindered by the lack of delivery vehicles that avoid cancer-induced organ dysfunction, which exacerbates carrier toxicity. We address this issue by reporting modular degradable dendrimers that achieve the required combi
Autor:
Michael E. Jung, Richard I. Gregory, David N. Chan, Jessica K Cinkornpumin, Xavier Gaeta, Liem H. Nguyen, William E. Lowry, Liu Xiaoguang, A. Liu, Hao Zhu, Syh-Jae Lin, Martina Roos, John P. Chute
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
The let-7 family of miRNAs has been shown to be crucial in many aspects of biology, from the regulation of developmental timing to cancer. The available methods to regulate this family of miRNAs have so far been mostly genetic and therefore not easil
Autor:
Jen Chieh Chuang, Amelia J. Eisch, Cemre Celen, Gijs W. E. Santen, Woo Ping Ge, Nadine Nijem, Liem H. Nguyen, Shuyuan Zhang, Craig M. Powell, Maria H. Chahrour, Angela K. Walker, Ibrahim Nassour, Fei Chen, Xuxu Sun, Levinus A. Bok, Albert Budhipramono, Hao Zhu, Meriel McEntagart, Evelien F. Gevers, Andrew S. Chung, Shari G. Birnbaum, Xin Luo
Publikováno v:
eLife
eLife, 6
eLife, Vol 6 (2017)
eLife, 6
eLife, Vol 6 (2017)
Sequencing studies have implicated haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O'Roak et al., 2012), intellectual disability (Deciphering Developmental Disorders