Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells.

Autor: Liegeois MA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA., Braunreuther M; Department of Chemical Engineering, Stanford University, Stanford, California, USA., Charbit AR; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA., Raymond WW; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA., Tang M; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, UCSF, San Francisco, California, USA., Woodruff PG; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, UCSF, San Francisco, California, USA., Christenson SA; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, UCSF, San Francisco, California, USA., Castro M; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas, USA., Erzurum SC; Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Israel E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Jarjour NN; Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Levy BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Moore WC; Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Wenzel SE; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Fuller GG; Department of Chemical Engineering, Stanford University, Stanford, California, USA., Fahy JV; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, UCSF, San Francisco, California, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Jun 18; Vol. 9 (15). Date of Electronic Publication: 2024 Jun 18.

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Autor: Everman JL; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Sajuthi SP; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Liegeois MA; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Jackson ND; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Collet EH; Department of Cell and Developmental Biology, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Peters MC; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Chioccioli M; Department of Genetics and Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Moore CM; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Patel BB; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Dyjack N; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Powell R; Department of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Rios C; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Montgomery MT; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Eng C; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Elhawary JR; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Mak ACY; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Hu D; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Huntsman S; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Salazar S; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Feriani L; Biological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Fairbanks-Mahnke A; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Zinnen GL; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Michel CR; Department of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Gomez J; Department of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Zhang X; Department of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Medina V; Centro de Neumología Pediatrica, San Juan, PR, USA., Chu HW; Department of Medicine, National Jewish Health, Denver, CO, USA., Cicuta P; Biological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Gordon ED; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Zeitlin P; Department of Pediatrics, National Jewish Health, Denver, CO, USA., Ortega VE; Mayo Clinic, Phoenix, AZ, USA., Reisdorph N; Department of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Dunican EM; School of Medicine, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Tang M; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Elicker BM; University of California-San Francisco, San Francisco, CA, USA., Henry TS; Duke University, Durham, NC, USA., Bleecker ER; Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA., Castro M; University of Kansas Medical Center, Kansas City, KS, USA., Erzurum SC; Cleveland Clinic, Cleveland, OH, USA., Israel E; Harvard University, Cambridge, MA, USA., Levy BD; Brigham and Women's Hospital and Harvard University, Cambridge, MA, USA., Mauger DT; Pennsylvania State University, Hershey, PA, USA., Meyers DA; Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA., Sumino K; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Gierada DS; Washington University, St. Louis, MO, USA., Hastie AT; Wake Forest University School of Medicine, Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston Salem, NC, USA., Moore WC; Wake Forest University School of Medicine, Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston Salem, NC, USA., Denlinger LC; University of Wisconsin-Madison, Madison, WI, USA., Jarjour NN; University of Wisconsin-Madison, Madison, WI, USA., Schiebler ML; University of Wisconsin-Madison, Madison, WI, USA., Wenzel SE; University of Pittsburgh, Pittsburgh, PA, USA., Woodruff PG; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Rodriguez-Santana J; Centro de Neumología Pediatrica, San Juan, PR, USA., Pearson CG; Department of Cell and Developmental Biology, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Burchard EG; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Fahy JV; Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Seibold MA; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA. seiboldm@njhealth.org.; Department of Pediatrics, National Jewish Health, Denver, CO, USA. seiboldm@njhealth.org.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA. seiboldm@njhealth.org.

Publikováno v: Nature communications [Nat Commun] 2024 May 09; Vol. 15 (1), pp. 3900. Date of Electronic Publication: 2024 May 09.