Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency.

Autor: Pillaiyar T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Wozniak M; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium., Abboud D; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium., Rasch A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Liebing AD; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany., Poso A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Stäubert C; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany., Laufer SA; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany., Hanson J; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium.; Laboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B-4000 Liège, Belgium.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 28; Vol. 66 (24), pp. 17118-17137. Date of Electronic Publication: 2023 Dec 07.

Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine.

Autor: Rabe P; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany., Liebing AD; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany., Krumbholz P; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany., Kraft R; Carl Ludwig Institute for Physiology, Faculty of Medicine, Leipzig University, Liebigstraße 27, 04103, Leipzig, Germany., Stäubert C; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany. Electronic address: claudia.staeubert@medizin.uni-leipzig.de.

Publikováno v: Cancer letters [Cancer Lett] 2022 Feb 01; Vol. 526, pp. 91-102. Date of Electronic Publication: 2021 Nov 20.

The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance.

Autor: Suchý T; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Zieschang C; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Popkova Y; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany., Kaczmarek I; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Weiner J; Department of Endocrinology, Medical Faculty, Leipzig University, Leipzig, Germany., Liebing AD; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Çakir MV; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Landgraf K; Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, Medical Faculty, Leipzig University, Leipzig, Germany., Gericke M; Institute for Anatomy and Cell biology, Medical Faculty, Halle University, Halle (Saale), Germany., Pospisilik JA; Van Andel Research Institute, Grand Rapids, MI, 49503, USA., Körner A; Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, Medical Faculty, Leipzig University, Leipzig, Germany., Heiker JT; IFB Adiposity Diseases, Leipzig University, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Dannenberger D; Leibniz Institute for Farm Animal Biology, Institute of Muscle Biology and Growth, Dummerstorf, Germany., Schiller J; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany., Schöneberg T; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Liebscher I; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. ines.liebscher@medizin.uni-leipzig.de., Thor D; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. doreen.thor@medizin.uni-leipzig.de.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2020 Oct; Vol. 44 (10), pp. 2124-2136. Date of Electronic Publication: 2020 Mar 19.