Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lidiya Obertas"'
Autor:
Ryosuke Tashiro, Dan Ozaki, Jesus Bautista-Garrido, Guanghua Sun, Lidiya Obertas, Alexis S. Mobley, Gab Seok Kim, Jaroslaw Aronowski, Joo Eun Jung
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5187 (2023)
Aging drives cognitive decline, and mitochondrial dysfunction is a hallmark of age-induced neurodegeneration. Recently, we demonstrated that astrocytes secrete functional mitochondria (Mt), which help adjacent cells to resist damage and promote repai
Externí odkaz:
https://doaj.org/article/9387680c9438496bad463c1172598444
Publikováno v:
Stroke. 54
After stroke, microglia and blood macrophages (MΦ) clear dead cells and cellular debris in the infarcted brain through phagocytosis. However, the phagocytic capability of MΦ declines with age. Age-related dysfunctions in MΦ also include reduced se
Autor:
Andreia Morais, Joseph J. Locascio, Lauren H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, Patrick D. Lyden, David C. Hess, Pradip K. Kamat, Mohammad Badruzzaman Khan, Krishnan Dhandapani, Ali S. Arbab, Shahneela Siddiqui, Cameron Smith, Mohammad Nisar, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Kai Wang, Tao Qin, Xuyan Jin, Taylan Denis Erdogan, Lili Yu, Joseph B. Mandeville, William Taylor Kimberly, Jonah Patrick Weigand Whittier, Eng Lo, Ken Arai, Klaus Van Leyen, Fahmeed Hyder, Jelena M. Mihailovic, Basavaraju G. Sanganahalli, Sebastian Diaz-Perez, Sofia E. Velazquez, Hannah E. Beatty, Conor Johnson, Alison L. Herman, Ligia S. B. Boisserand, Emma Immakavar, Raymond C. Koehler, Ted Dawson, Valina Dawson, Yanrong Shi, Brooklyn Avery, Steven Lannon, Adnan Bibic, Kazi Akhter, Senthilkumar S. Karuppagounder, Louise D. McCullough, Lidiya Obertas, Andrew Goh, Shuning Huang, Anjali Chauhan
Publikováno v:
Stroke.
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization an
Autor:
Ryosuke Tashiro, Jesus Bautista-Garrido, Dan Ozaki, Guanghua Sun, Lidiya Obertas, Alexis S Mobley, Gab Seok Kim, Jaroslaw Aronowski, Joo Eun Jung
Publikováno v:
J Neurosci
Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions on entering adjacent cells. We recently demonstrated that these released Mts could enter microglia to promote their reparative/prophagocytic phenotype that
Autor:
Robert W. Mays, Annelies Bogaerts, Andrew Goh, Xiurong Zhao, Guanghua Sun, Sean I Savitz, Jaroslaw Aronowski, Sarah A. Busch, Lidiya Obertas, Shun-Ming Ting
Publikováno v:
Stroke. 52
Background: Multipotent adult progenitor cells (MAPC) are an adherent adult stem cell being evaluated as a treatment for ischemic stroke in humans under the name MultiStem®. However, the efficacy of MAPC cells for the treatment of intracerebral hemo
Autor:
Lidiya Obertas, Shun-Ming Ting, Mercedes Ricote, Guanghua Sun, Xiurong Zhao, Jaroslaw Aronowski
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Instituto de Salud Carlos III (ISCIII)
Background and Purpose— Phagocytic cells, such as microglia and blood-derived macrophages, are a key biological modality responsible for phagocytosis-mediated clearance of damaged, dead, or displaced cells that are compromised during senescence or
Autor:
Lidiya Obertas, Joo Eun Jung, Jesus Bautista Garrido, Guanghua Sun, Alexis S Mobley, Shun-Ming Ting, Xiurong Zhao, Jaroslaw Aronowski
Publikováno v:
J Neurosci
Astrocytes are an integral component of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries, such as stroke. One process by which astrocytes modulate homeostasis is the release of functional mitochondria (
Autor:
Juan J Garrido, Shun-Ming Ting, Lidiya Obertas, Xiurong Zhao, Jaroslaw Aronowski, Guanghua Sun
Publikováno v:
Stroke. 49
Microglia/macrophage (MΦ) are immune response cells with function in clearing cell debris and tissue repair after ischemic brain damage. Retinoid X receptor alpha (RXRα) is a pleiotropic transcription factor regulating cell differentiation, lipid/g
Autor:
Xueping Zheng, Jesus Bautista Garrido, Xiurong Zhao, Meaghan Roy-O'Reilly, Shun-Ming Ting, Lidiya Obertas, Guanghua Sun, Alexis S Mobley, Jaroslaw Aronowski, Joo Eun Jung, Marian L. Kruzel
Publikováno v:
Stroke. 49(5)
Background and Purpose— Intracerebral hemorrhage (ICH) is a devastating disease with a 30-day mortality of ~50%. There are no effective therapies for ICH. ICH results in brain damage in 2 major ways: through the mechanical forces of extravasated bl
Autor:
Lidiya Obertas, Beatrisa Lerman, Kentaro Tanaka, Cara Haymaker, Roza Nurieva, Anupama Sahoo, Karen Clise-Dwyer, John S. McMurray, Andrei Alekseev
Publikováno v:
Nature Communications
Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown