Coordination of dual incision and repair synthesis in human nucleotide excision repair

Autor: Jacqueline H. Enzlin, Adebanke F. Fagbemi, Giuseppina Giglia-Mari, Wim Vermeulen, Stuart G. Clarkson, Lidija Staresincic, Audrey M. Gourdin, Isabelle Dunand-Sauthier, Orlando D. Schärer, Nils Wijgers

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2009, 28 (8), pp.1111-1120. ⟨10.1038/emboj.2009.49⟩
EMBO Journal, Vol. 28, No 8 (2009) pp. 1111-1120
EMBO Journal, 28(8), 1111-1120. Wiley-Blackwell

Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the involved proteins at sites of DNA damage. Following damage recognition, dual incision 5' to the lesion by ERCC1-XPF and 3' to the lesion by XPG leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272338a7bb4b863e64e94c3bd36259ba
https://doi.org/10.1038/emboj.2009.49

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity

Autor: Marcel Hohl, Lidija Staresincic, Isabelle Dunand-Sauthier, Mauro Modesti, Stuart G. Clarkson, Pascale Jaquier-Gubler, Fabrizio Thorel, Orlando D. Schärer

Publikováno v: Nucleic Acids Research

FEN-1 and XPG are members of the FEN-1 family of structure-specific nucleases, which share a conserved active site. FEN-1 plays a central role in DNA replication, whereas XPG is involved in nucleotide excision repair (NER). Both FEN-1 and XPG are act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f869d5507cd86941b3c5ca8828f198df
https://doi.org/10.1093/nar/gkm092