Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Lidija Klampfer"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45462 (2012)
Tumor cells become addicted to both activated oncogenes and to proliferative and pro-survival signals provided by the abnormal tumor microenvironment. Although numerous soluble factors have been identified that shape the crosstalk between tumor cells
Externí odkaz:
https://doaj.org/article/182b07f0836340ba97743c838448a322
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11700 (2010)
We recently reported that colon tumor cells stimulate macrophages to release IL-1beta, which in turn inactivates GSK3beta and enhances Wnt signaling in colon cancer cells, generating a self-amplifying loop that promotes the growth of tumor cells.Here
Externí odkaz:
https://doaj.org/article/122a9310e0ef4f098ebbe1b7f1038705
Autor:
John M. Mariadason, Roman Perez Soler, Leonard H. Augenlicht, Lidija Klampfer, Joongho Shin, Diego Arango, Shannon Nasser, Do-Sun Byun, Yi-He Ling, Cristina Montagna, Andrew J. Wilson, Sanjay Goel, Minaxi Jhawer
Supplementary Figures 1-5 from PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bc2583aa2cf2f45714c11092f202b8
https://doi.org/10.1158/0008-5472.22374423
https://doi.org/10.1158/0008-5472.22374423
Supplementary Figure 2 from Histone Deacetylase Inhibitors Induce Cell Death Selectively in Cells That Harbor Activated kRasV12: The Role of Signal Transducers and Activators of Transcription 1 and p21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd34fcbd13ac903fc97b3cea34b3c1e
https://doi.org/10.1158/0008-5472.22371302
https://doi.org/10.1158/0008-5472.22371302
Supplementary Figure 1 from Histone Deacetylase Inhibitors Induce Cell Death Selectively in Cells That Harbor Activated kRasV12: The Role of Signal Transducers and Activators of Transcription 1 and p21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b455bacb7f27cf9a1990246cf2202c
https://doi.org/10.1158/0008-5472.22371305.v1
https://doi.org/10.1158/0008-5472.22371305.v1
Histone deacetylase (HDAC) inhibitors (HDACi) show potent and selective antitumor activity despite the fact that they induce histone hyperacetylation in both normal and tumor cells. In this study, we showed that the inducible expression of kRasV12 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::309f73538653faadedcf9aaea6cde909
https://doi.org/10.1158/0008-5472.c.6496736
https://doi.org/10.1158/0008-5472.c.6496736
Autor:
John M. Mariadason, Roman Perez Soler, Leonard H. Augenlicht, Lidija Klampfer, Joongho Shin, Diego Arango, Shannon Nasser, Do-Sun Byun, Yi-He Ling, Cristina Montagna, Andrew J. Wilson, Sanjay Goel, Minaxi Jhawer
Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). Although approved for use in EGFR-overexpressing advanced colorectal cancer, recent studies have shown a lack of association between EGFR overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a462027e062b165a648ae4e61771aa38
https://doi.org/10.1158/0008-5472.c.6497442
https://doi.org/10.1158/0008-5472.c.6497442
Autor:
Vishnu C. Damalanka, Jorine J. L. P. Voss, Matthew W. Mahoney, Tina Primeau, Shunqiang Li, Lidija Klampfer, James W. Janetka
Publikováno v:
J Med Chem
Hepatocyte growth factor (HGF), the ligand for the MET receptor tyrosine kinase, is a tumor-promoting factor that is abundant in the tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more of the serine endopeptidases matrip
Autor:
Ramona Graves-Deal, Vivian T. Jones, Galina T. Bogatcheva, Zheng Cao, Sarah J. Harmych, Vishnu Damalanka, Lidija Klampfer, Robert J. Coffey, James W. Janetka, Bhuminder Singh
Publikováno v:
Cancer Research. 82:PR010-PR010
We have previously identified that activation of receptor tyrosine kinases (RTKs), MET and RON contributed to resistance to the EGF receptor (EGFR)-directed therapeutic antibody, cetuximab. These findings originated from our in vitro 3D type I collag
Autor:
Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer
Publikováno v:
bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/
https://europepmc.org/articles/PMC8204910/