Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lidia Węglińska"'
Autor:
Lidia Węglińska, Adrian Bekier, Nazar Trotsko, Barbara Kaproń, Tomasz Plech, Katarzyna Dzitko, Agata Paneth
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2621-2634 (2022)
A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on the identification of the com
Externí odkaz:
https://doaj.org/article/79d58e45c8734949b193085685825372
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1145-1164 (2021)
We report herein anti-proliferation effects of 4-arylthiosemicarbazides, with a cyclopentane substitution at N1 position, on highly virulent RH strain of Toxoplasma gondii. Among them, the highest in vitro anti-Toxoplasma activity was found with the
Externí odkaz:
https://doaj.org/article/c469cec21766439e99c28e34fbdb3bfc
Autor:
Lidia Węglińska, Adrian Bekier, Katarzyna Dzitko, Barbara Pacholczyk-Sienicka, Łukasz Albrecht, Tomasz Plech, Piotr Paneth, Agata Paneth
Publikováno v:
Cells, Vol 10, Iss 5, p 1053 (2021)
Congenital and acquired toxoplasmosis caused by the food- and water-born parasite Toxoplasma gondii (T. gondii) is one of the most prevalent zoonotic infection of global importance. T. gondii is an obligate intracellular parasite with limited capacit
Externí odkaz:
https://doaj.org/article/0073550043ed4ae7a51c58b22887d0d2
Autor:
Agata Paneth, Lidia Węglińska, Adrian Bekier, Edyta Stefaniszyn, Monika Wujec, Nazar Trotsko, Anna Hawrył, Miroslaw Hawrył, Katarzyna Dzitko
Publikováno v:
Molecules, Vol 24, Iss 8, p 1618 (2019)
Employing a simple synthetic protocol, a series of highly effective halogen-substituted imidazole-thiosemicarbazides with anti-Toxoplasma gondii effects against the RH tachyzoites, much better than sulfadiazine, were obtained (IC50s 10.30—113.45 µ
Externí odkaz:
https://doaj.org/article/9957c93ab72f4fa7b5d03bd36871ef9a
Autor:
Agata Paneth, Lidia Węglińska, Adrian Bekier, Edyta Stefaniszyn, Monika Wujec, Nazar Trotsko, Katarzyna Dzitko
Publikováno v:
Molecules, Vol 24, Iss 3, p 614 (2019)
One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based
Externí odkaz:
https://doaj.org/article/68e1cd144dea4465ab83dd4dc44fb185
Autor:
Lidia, Węglińska, Adrian, Bekier, Nazar, Trotsko, Barbara, Kaproń, Tomasz, Plech, Katarzyna, Dzitko, Agata, Paneth
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 37(1)
A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on the identification of the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ccfe920c7220fbce0485bf8cd349e92
https://pubmed.ncbi.nlm.nih.gov/36165032
https://pubmed.ncbi.nlm.nih.gov/36165032
Autor:
Katarzyna Dzitko, Barbara Pacholczyk-Sienicka, Łukasz Albrecht, Piotr Paneth, Tomasz Plech, Adrian Bekier, Lidia Węglińska, Agata Paneth
Publikováno v:
Cells, Vol 10, Iss 1053, p 1053 (2021)
Cells
Volume 10
Issue 5
Cells
Volume 10
Issue 5
Congenital and acquired toxoplasmosis caused by the food- and water-born parasite Toxoplasma gondii (T. gondii) is one of the most prevalent zoonotic infection of global importance. T. gondii is an obligate intracellular parasite with limited capacit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786a367c2eb9f0c5d5f47d15a23f708d
https://www.mdpi.com/2073-4409/10/5/1053
https://www.mdpi.com/2073-4409/10/5/1053
Autor:
Edyta Stefaniszyn, Nazar Trotsko, Monika Wujec, Adrian Bekier, Agata Paneth, Katarzyna Dzitko, Lidia Węglińska
Publikováno v:
Molecules, Vol 24, Iss 3, p 614 (2019)
Molecules
Volume 24
Issue 3
Molecules
Volume 24
Issue 3
One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3040003054e54ab2e7124e1e0dc9d740
https://www.mdpi.com/1420-3049/24/3/614
https://www.mdpi.com/1420-3049/24/3/614
Autor:
Anna Hawrył, Adrian Bekier, Katarzyna Dzitko, Monika Wujec, Agata Paneth, Edyta Stefaniszyn, Mirosław A. Hawrył, Lidia Węglińska, Nazar Trotsko
Publikováno v:
Molecules, Vol 24, Iss 8, p 1618 (2019)
Molecules
Volume 24
Issue 8
Molecules
Volume 24
Issue 8
Employing a simple synthetic protocol, a series of highly effective halogen-substituted imidazole-thiosemicarbazides with anti-Toxoplasma gondii effects against the RH tachyzoites, much better than sulfadiazine, were obtained (IC50s 10.30&mdash
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccf65a04d7558277c85b5de2dd04222
https://doi.org/10.3390/molecules24081618
https://doi.org/10.3390/molecules24081618
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:7583-7585
This article reports anti- Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c362a66673c6cd429002ed147c8e8e
https://doi.org/10.1128/aac.03832-14
https://doi.org/10.1128/aac.03832-14