Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lidia V. Kulemina"'
Publikováno v:
Biochemical and Biophysical Research Communications. 374:210-213
The Izh2p protein from Saccharomyces cerevisiae is a receptor for the plant antifungal protein, osmotin. Since Izh2p is conserved in fungi, understanding its biochemical function could inspire novel strategies for the prevention of fungal growth. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae1542e101b3612f85281e575ef7b5c
https://doi.org/10.1016/j.bbrc.2008.07.002
https://doi.org/10.1016/j.bbrc.2008.07.002
Autor:
Lidia V. Kulemina, David A. Ostrov
Publikováno v:
Journal of biomolecular screening. 16(8)
The authors describe a structure-based strategy to identify therapeutically beneficial off-target effects by screening a chemical library of Food and Drug Administration (FDA)-approved small-molecule drugs matching pharmacophores defined for specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71d601d1a6b717bdaebc7905f66cdc8
https://pubmed.ncbi.nlm.nih.gov/21859683
https://pubmed.ncbi.nlm.nih.gov/21859683
Autor:
Lidia V. Kulemina, Altin Gjymishka, Mohan K. Raizada, David A. Ostrov, Vinayak Shenoy, Michael J. Katovich
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e3bfe0516ac159e40d5c67cdb3080a
https://doi.org/10.1096/fasebj.24.1_supplement.1032.3
https://doi.org/10.1096/fasebj.24.1_supplement.1032.3
Publikováno v:
Molecular Cancer Therapeutics. 12:A25-A25
Graph theory approaches are now increasingly used to navigate through big data from “omics” applications for delineating signature events in cancer subtypes, identification of new molecular targets and assigning significance of specific mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4956c38e0c3a2d5e1471c2abbaecf6c0
https://doi.org/10.1158/1535-7163.targ-13-a25
https://doi.org/10.1158/1535-7163.targ-13-a25
Publikováno v:
Cancer Research. 73:631-631
Thymidylate synthase (TS) is a well-established chemotherapy target frequently overexpressed in cancer. Multiple clinical studies demonstrated that high levels of TS correlate with the disease stage and resistance to fluoropyrimidine chemotherapy. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a545c2421c747a55ef41ac060093be6c
https://doi.org/10.1158/1538-7445.am2013-631
https://doi.org/10.1158/1538-7445.am2013-631
Autor:
Min Chen, Carmen J. Allegra, Daniil Shabashvili, Lidia V. Kulemina, Kevin Morgan, Maria Zajac-Kaye
Publikováno v:
Cancer Research. 72:3892-3892
Thymidylate synthase (TS) inhibitors are a class of antineoplastic agents widely used for the treatment of gastrointestinal, breast, ovarian and other cancers. TS catalyzes reductive methylation of dUMP to dTMP and serves as the sole de novo source o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e732e3162b34fdd6babaae117c74969
https://doi.org/10.1158/1538-7445.am2012-3892
https://doi.org/10.1158/1538-7445.am2012-3892