Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lidia Gurba-Bryśkiewicz"'
Autor:
Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Damian A. Smuga, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2752 (2023)
The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA are lipid nanoparticles (LNPs). Many
Externí odkaz:
https://doaj.org/article/17c6955924224311a5546027e7673973
Autor:
Wojciech Pietruś, Mariola Stypik, Marcin Zagozda, Martyna Banach, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Arkadiusz Leniak, Rafał Kurczab, Zbigniew Ochal, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Molecules, Vol 28, Iss 8, p 3531 (2023)
As a member of the class I PI3K family, phosphoinositide 3-kinase δ (PI3Kδ) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a potential and promising therap
Externí odkaz:
https://doaj.org/article/62c0899b09d24354ba8846e2be2ab71f
Autor:
Ewelina Bukowska-Olech, Anna Sowińska-Seidler, Dawid Larysz, Paweł Gawliński, Grzegorz Koczyk, Delfina Popiel, Lidia Gurba-Bryśkiewicz, Anna Materna-Kiryluk, Zuzanna Adamek, Aleksandra Szczepankiewicz, Paweł Dominiak, Filip Glista, Karolina Matuszewska, Aleksander Jamsheer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background: Craniosynostosis (CS) represents a highly heterogeneous genetic condition whose genetic background has not been yet revealed. The abnormality occurs either in isolated form or syndromic, as an element of hundreds of different inborn syndr
Externí odkaz:
https://doaj.org/article/fbd552ed03f34a65b30b004ba44b40f1
Autor:
Mariola Stypik, Stanisław Michałek, Nina Orłowska, Marcin Zagozda, Maciej Dziachan, Martyna Banach, Paweł Turowski, Paweł Gunerka, Daria Zdżalik-Bielecka, Aleksandra Stańczak, Urszula Kędzierska, Krzysztof Mulewski, Damian Smuga, Wioleta Maruszak, Lidia Gurba-Bryśkiewicz, Arkadiusz Leniak, Wojciech Pietruś, Zbigniew Ochal, Mateusz Mach, Beata Zygmunt, Jerzy Pieczykolan, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 927 (2022)
Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and the
Externí odkaz:
https://doaj.org/article/a571ed7c657c4ae3a404d1e13d1d6daf
Autor:
Mariola Stypik, Marcin Zagozda, Stanisław Michałek, Barbara Dymek, Daria Zdżalik-Bielecka, Maciej Dziachan, Nina Orłowska, Paweł Gunerka, Paweł Turowski, Joanna Hucz-Kalitowska, Aleksandra Stańczak, Paulina Stańczak, Krzysztof Mulewski, Damian Smuga, Filip Stefaniak, Lidia Gurba-Bryśkiewicz, Arkadiusz Leniak, Zbigniew Ochal, Mateusz Mach, Karolina Dzwonek, Monika Lamparska-Przybysz, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 949 (2022)
Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cell
Externí odkaz:
https://doaj.org/article/4dd8c9f6c70e4b8898c041fd13130a7c
Autor:
Piotr Pankiewicz, Marcin Szybiński, Katarzyna Kisielewska, Filip Gołębiowski, Patryk Krzemiński, Izabela Rutkowska-Włodarczyk, Rafał Moszczyński-Pętkowski, Lidia Gurba-Bryśkiewicz, Monika Delis, Krzysztof Mulewski, Damian Smuga, Jakub Dominowski, Artur Janusz, Michał Górka, Krzysztof Abramski, Agnieszka Napiórkowska, Marcin Nowotny, Krzysztof Dubiel, Katarzyna Kalita, Maciej Wieczorek, Jerzy Pieczykolan, Mikołaj Matłoka
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 704 (2021)
TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF’s action has been unsuccessful. Several molecules exerting antidepr
Externí odkaz:
https://doaj.org/article/9bb1dda14c4f450caccc553dfbb7d53e
Autor:
Stanisław Michałek, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Marcin Zagozda, Anna M. Maj, Zbigniew Ochal, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
RSC Advances. 12:33605-33611
DoE study of the aerobic flow Pd-catalyzed oxidation of an alcohol to an aldehyde in the synthesis of PI3Kδ inhibitor. The evaluation of green metrics show that the process is sustainable in comparison with two already known stoichiometric methods.
Autor:
Lidia Gurba-Bryśkiewicz, Urszula Dawid, Damian A. Smuga, Wioleta Maruszak, Monika Delis, Krzysztof Szymczak, Bartosz Stypik, Aleksandra Moroz, Aleksandra Błocka, Michał Mroczkiewicz, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10720
The purpose of this work was to demonstrate the use of the AQbD with the DOE approach to the methodical step-by-step development of a UHPLC method for the quantitative determination of the impurity profile of new CPL409116 substance (JAK/ROCK inhibit