Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders

Autor: Joanna Kałafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Müller, Lidia Borkiewicz

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 16, p 12579 (2023)

Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studie

Externí odkaz: https://doaj.org/article/8d2b67e2059b46c4bae2eede396ef578

Functional Analysis of the Ribosomal uL6 Protein of Saccharomyces cerevisiae

Autor: Lidia Borkiewicz, Mateusz Mołoń, Eliza Molestak, Przemysław Grela, Patrycja Horbowicz-Drożdżal, Leszek Wawiórka, Marek Tchórzewski

Publikováno v: Cells, Vol 8, Iss 7, p 718 (2019)

The genome-wide duplication event observed in eukaryotes represents an interesting biological phenomenon, extending the biological capacity of the genome at the expense of the same genetic material. For example, most ribosomal proteins in Saccharomyc

Externí odkaz: https://doaj.org/article/9bb5e79ade1246e4912f7d64010c24b6

Vorinostat (SAHA) and Breast Cancer: An Overview

Autor: Syeda Afshan, Estera Okon, Wirginia Kukula-Koch, Marta Halasa, Anna Wawruszak, Lidia Borkiewicz

Publikováno v: Cancers
Cancers, Vol 13, Iss 4700, p 4700 (2021)

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020 worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully understood, and effective therapy is one of the most important challenges i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc62fa6e750279219b91d69887c83a3
https://pubmed.ncbi.nlm.nih.gov/34572928

Sintered nanoporous biosilica diatom frustules as high efficiency cell-growth and bone-mineralisation platforms

Autor: Adolfo Rivero-Müller, Adeleke Amoda, Lidia Borkiewicz, Parvez Alam

Publikováno v: Amoda, A, Borkiewicz, L, Rivero-Muller, A & Alam, P 2020, ' Sintered nanoporous biosilica diatom frustules as high-efficiency cell-growth and bone-mineralisation platforms ', Materials Today Communications, vol. 24, 100923 . https://doi.org/10.1016/j.mtcomm.2020.100923

In this paper, we disclose a novel biomaterial with a considerable capacity for cell growth and bone mineralisation. The biomaterial is manufactured by sintering diatom (Cyclostephanos sp.) frustules under two different moulding pressures at temperat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d271d3d557d32cce1ee2c9f8643a74db
https://doi.org/10.1016/j.mtcomm.2020.100923

Multiplication of Ribosomal P-Stalk Proteins Contributes to the Fidelity of Translation

Autor: Monika Szajwaj, Barbara Michalec-Wawiórka, Leszek Wawiórka, Lidia Borkiewicz, Mateusz Molon, Eliza Molestak, Aleksandra Boguszewska, Marek Tchórzewski, Przemysław Grela

Publikováno v: Molecular and cellular biology. 37(17)

The P-stalk represents a vital element within the ribosomal GTPase-associated center, which represents a landing platform for translational GTPases. The eukaryotic P-stalk exists as a uL10-(P1-P2)2 pentameric complex, which contains five identical C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801de46100390087a67d3fd996356d7e
https://pubmed.ncbi.nlm.nih.gov/28606931