Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Autor: Helmut Pein, Alexia Ville, Simona Pace, Veronika Temml, Ulrike Garscha, Martin Raasch, Khaled Alsabil, Guillaume Viault, Chau-Phi Dinh, David Guilet, Fabiana Troisi, Konstantin Neukirch, Stefanie König, Rosella Bilancia, Birgit Waltenberger, Hermann Stuppner, Maria Wallert, Stefan Lorkowski, Christina Weinigel, Silke Rummler, Marc Birringer, Fiorentina Roviezzo, Lidia Sautebin, Jean-Jacques Helesbeux, Denis Séraphin, Alexander S. Mosig, Daniela Schuster, Antonietta Rossi, Pascal Richomme, Oliver Werz, Andreas Koeberle

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synth

Externí odkaz: https://doaj.org/article/8f5b1e43017943509f14b4b68fe07ec5

The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury

Autor: Antonietta Rossi, Carlo Pergola, Salvatore Cuzzocrea, Lidia Sautebin

Publikováno v: The Scientific World Journal, Vol 7, Pp 56-74 (2007)

The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, t

Externí odkaz: https://doaj.org/article/9c7bafbca4c94fa68c99dcc110513301

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Autor: Simona Pace, Daniela Schuster, Marc Birringer, Maria Wallert, Christina Weinigel, Hermann Stuppner, Denis Séraphin, David Guilet, Veronika Temml, Martin Raasch, Silke Rummler, Helmut Pein, Fiorentina Roviezzo, Jean-Jacques Helesbeux, Rosella Bilancia, Lidia Sautebin, Stefanie König, Guillaume Viault, Chau-Phi Dinh, Alexia Ville, Ulrike Garscha, Birgit Waltenberger, Alexander S. Mosig, Stefan Lorkowski, Andreas Koeberle, Fabiana Troisi, Pascal Richomme, Oliver Werz, Khaled Alsabil, Antonietta Rossi, Konstantin Neukirch

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩

Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human vitamin E metabolites, that long-chain ω-carboxylates are potent allosteric inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfee7afdff0d4990f14ad8886b080055
http://link.springer.com/article/10.1038/s41467-018-06158-5

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition

Autor: Maria Voelkel, Helen Morrison, Antonietta Rossi, Solveigh C. Koeberle, Oliver Werz, Helmut Pein, Lidia Sautebin, Andreas Koeberle, Maria Thürmer, Konstantin Loeser, Freya Schneider

Publikováno v: The FASEB Journal. 31:4458-4471

Protein kinases, including the serine/threonine kinase Akt, mediate manifold bioactivities of vitamin A, although the mechanisms behind the sustained kinase activation are diffuse. To investigate the role of cellular lipids as targetable factors in A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adaddd7cc5cf0fdaf9e3abfab8684c6
https://doi.org/10.1096/fj.201700078r

Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold

Autor: Maurizio Anzini, Giulia Chemi, Alessia Chelini, Germano Giuliani, Angela Di Capua, Lorenzo Di Cesare Mannelli, Gianluca Giorgi, Concettina La Motta, Annalisa Reale, Massimo Valoti, Antonietta Rossi, Lidia Sautebin, Simona Pace, Marco Paolino, Elena Lucarini, Andrea Cappelli, Simone Brogi, Alessandro Grillo, Carla Ghelardini

A novel series of 1,5-diarylpyrrol-3-sulfur derivatives (10–12) was synthesized and characterized by NMR and mass spectroscopy and x-ray diffraction. The biological activity of these compounds was evaluated in in vitro and in vivo tests to assess t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6820359b41e3db181ca2676dc960a721
http://hdl.handle.net/11588/766499