Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Lidia, Sambucetti"'
Autor:
Michal Avital-Shmilovici, Xiaohe Liu, Thomas Shaler, Andrew Lowenthal, Pauline Bourbon, Janey Snider, Arlyn Tambo-Ong, Claire Repellin, Kenya Yniguez, Lidia Sambucetti, Peter B. Madrid, Nathan Collins
Publikováno v:
ACS Central Science, Vol 8, Iss 1, Pp 86-101 (2022)
Externí odkaz:
https://doaj.org/article/ce6b89713ee94aebad35b3383f84a31b
Autor:
Yihui Shi, Walter Bray, Alexander J Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R Scott Lokey, Thomas R Webb
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233672 (2020)
Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a library that
Externí odkaz:
https://doaj.org/article/aee47b160f21479b987ca0add01dfec1
Autor:
Xiaohe Liu, Thomas Shaler, Nathan Collins, Claire E. Repellin, Janey Snider, Kenya Yniguez, Andrew C. Lowenthal, Pauline Bourbon, Lidia Sambucetti, Arlyn Tambo-ong, Michal Avital-Shmilovici, Peter B. Madrid
Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discovery. We devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fcf0471ccbd1cfc97fd7c4c0c6edee
https://doi.org/10.26434/chemrxiv-2021-6wxh5-v2
https://doi.org/10.26434/chemrxiv-2021-6wxh5-v2
Autor:
Jason E. Long, Soochan Kim, Ha Yeong Kim, Dong Guk Shin, Dong Hyun Park, Robert Warne, Akash Das, Ganapati Hegde, Padmini Narayanan, Lidia Sambucetti, Brenda Chan, Xi Chen, Jae H. Chang, Paul Gibbons, Jessica Sun, Matthew Panuwat, Lori S. Friedman, Melissa R. Junttila
Publikováno v:
Cancer Research. 82:3335-3335
Exon 20 genomic insertions of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are oncogenic drivers and are most commonly found in non-small cell lung cancer (NSCLC). NSCLC patients with exon 20 insert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f8560e971060390f9ffac8101bdc5e
https://doi.org/10.1158/1538-7445.am2022-3335
https://doi.org/10.1158/1538-7445.am2022-3335
Autor:
Brent L. Nannenga, James J. Hsieh, Jose M. Martin-Garcia, Nirupa Nagaratnam, Dewight Williams, Darren Thifault, Mary Stofega, Silvia Delker, Petra Fromme, Lidia Sambucetti, Rebecca Jernigan, Andrew Flint, Janey Snider, Thomas E. Edwards
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
19 pags., 7 figs., 2 tabs.
Taspase1 is an Ntn-hydrolase overexpressed in primary human cancers, coordinating cancer cell proliferation, invasion, and metastasis. Loss of Taspase1 activity disrupts proliferation of human cancer cells in vitro and
Taspase1 is an Ntn-hydrolase overexpressed in primary human cancers, coordinating cancer cell proliferation, invasion, and metastasis. Loss of Taspase1 activity disrupts proliferation of human cancer cells in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d04a6f6ad95162391f8a23bf749667
https://pubmed.ncbi.nlm.nih.gov/33784495
https://pubmed.ncbi.nlm.nih.gov/33784495
Autor:
Brent L. Nannenga, Mary Stofega, Andrew Flint, Thomas Edwards, James J. Hsieh, Nirupa Nagaratnam, Silvia Delker, Rebecca Jernigan, Petra Fromme, Janey Snider, Jose M. Martin-Garcia, Darren Thifault, Dewight Williams, Lidia Sambucetti
Proteases can play essential roles in severe human pathology, ranging from degenerative and inflammatory illnesses to infectious diseases, with some, such as Taspase1, involved in growth and progression of tumors at primary and metastatic sites. Tasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c91229e25e55da9f8305610df7d87d
https://doi.org/10.1101/2020.11.26.400622
https://doi.org/10.1101/2020.11.26.400622
Autor:
Silvia Delker, Dewight Williams, Thomas E. Edwards, James J. Hsieh, Nirupa Nagaratnam, Andrew Flint, Janey Sneider, Rebecca Jernigan, Brent L. Nannenga, Jose M. Martin-Garcia, Mary Stofega, Lidia Sambucetti, Darren Thifault
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 77:a110-a110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1636fdd234f4174331a41e9c871379a
https://doi.org/10.1107/s0108767321098895
https://doi.org/10.1107/s0108767321098895
Publikováno v:
Molecular Imaging, Vol 3 (2004)
Bioluminescent and fluorescent reporters are finding increased use in optical molecular imaging in small animals. In the work presented here, issues related to the sensitivity of in vivo detection are examined for standard reporters. A high-sensitivi
Externí odkaz:
https://doaj.org/article/e790937602494046a5c62d8d1dacd885
Autor:
Lidia Sambucetti, Aras N. Mattis, James A. Wells, Adam R. Renslo, Yihui Shi, Byron Hann, Shaun D. Fontaine, Benjamin Spangler
Publikováno v:
Journal of Medicinal Chemistry
Here we describe a new approach for tumor targeting in which augmented concentrations of Fe(II) in cancer cells and/or the tumor microenvironment triggers drug release from an Fe(II)-reactive prodrug conjugate. The 1,2,4-trioxolane scaffold developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d06ffedb335426fd875f48a77e3e2
https://doi.org/10.1021/acs.jmedchem.6b01470
https://doi.org/10.1021/acs.jmedchem.6b01470
Autor:
Puja Patel, Claire E. Repellin, Lidia Sambucetti, Haritha K. Duggireddy Lakshmireddy, Harold S. Javitz, Javier F. Alcudia, Lucia Beviglia, Priya Ganesan, Parijat Bhatnagar
Publikováno v:
Adv Biosyst
A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens. These cell lines also express fluorescent and bioluminescent reporter transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2951b12087127a8b4ac6994774b2d3ab
https://pubmed.ncbi.nlm.nih.gov/32293122
https://pubmed.ncbi.nlm.nih.gov/32293122