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Akademický článek

Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

Autor: Wantae Kim, Tzu-Yu Chen, Lide Cha, Grace Zhou, Kristi Xing, Nicholas Koenig Canty, Yan Zhang, Wei-chen Chang

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

While canonical oxygen-rebound pathway has been utilized by several Fe/2OG enzymes, insights into the desaturation process remain to be elucidated. Here, the authors suggest that a carbocation might be deployed to enable chemically divergent desatura

Externí odkaz: https://doaj.org/article/7e3eaa79feae4334b0e2f2d6f95b5a6a

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Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis

Autor: Olivia M. Manley, Han N. Phan, Allison K. Stewart, Dontae A. Mosley, Shan Xue, Lide Cha, Hongxia Bai, Veda C. Lightfoot, Pierson A. Rucker, Leonard Collins, Taufika Islam Williams, Wei-Chen Chang, Yisong Guo, Thomas M. Makris

Publikováno v: Proceedings of the National Academy of Sciences. 119

Chlamydia protein associating with death domains (CADD) is involved in the biosynthesis of para -aminobenzoate (pABA), an essential component of the folate cofactor that is required for the survival and proliferation of the human pathogen Chlamydia t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::402ed51dbe4cea176cb69ae7048ccedf
https://doi.org/10.1073/pnas.2210908119

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Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

Autor: Sergey Milikisiyants, Madison Davidson, Yisong Guo, Wei-Chen Chang, Tatyana I. Smirnova, Alex I. Smirnov, Shan Xue, Lide Cha

Publikováno v: Biochemistry

Applying enzymatic reactions to produce useful molecules is a central focus of chemical biology. Iron and 2-oxoglutarate (Fe/2OG) enzymes are found in all kingdoms of life and catalyze a broad array of oxidative transformations. Herein, we demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e12fcb6ec3a19538a2de2635beea7a
https://doi.org/10.1021/acs.biochem.0c00289

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Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis

Autor: Tzu-Yu Chen, Ziyang Zheng, Xuan Zhang, Jinfeng Chen, Lide Cha, Yijie Tang, Yisong Guo, Jiahai Zhou, Binju Wang, Hung-wen Liu, Wei-chen Chang

Publikováno v: ACS Catal

Despite the diversity of reactions catalyzed by 2-oxoglutarate-dependent nonheme iron (Fe/2OG) enzymes identified in recent years, only a limited number of these enzymes have been investigated in mechanistic detail. In particular, several Fe/2OG-depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd279f185eba83f69147cff358a0dcac
https://europepmc.org/articles/PMC9390461/

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An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2

Autor: Lide Cha, Wei-Chen Chang

Publikováno v: Trends in Chemistry. 2:1040-1042

A novel strategy to introduce C-isotopes at the carboxylate group has been discovered. Through ‘simple' CO2 exchange under mild conditions, the C-isotope can be incorporated effectively and has been demonstrated in a variety of biologically importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db0e7f0632290ea44c7beade509e8bf6
https://doi.org/10.1016/j.trechm.2020.10.004

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Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

Autor: Wei-Chen Chang, Nei-Li Chan, Yisong Guo, Lide Cha, Jhih-Liang Huang, Jikun Li, Maria Kurnikova, Justin L. Lee, Igor V. Kurnikov, Hsuan-Jen Liao, Te-Sheng Lin, Yijie Tang

Publikováno v: J Am Chem Soc

Mechanisms of enzymatic epoxidation via oxygen atom transfer (OAT) to an olefin moiety is mainly derived from the studies on thiolate-heme containing epoxidases, such as cytochrome P450 epoxidases. The molecular basis of epoxidation catalyzed by nonh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ce6e1abaa24f4ee0ff3cb417dd45d2
https://pubmed.ncbi.nlm.nih.gov/32131594

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