Výsledky vyhledávání - "Lida H. Kimmel"

Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3

Autor: John J. O'Shea, Andrea Lengi, Fabio Candotti, Rebecca H. Buckley, Paul S. Changelian, Joseph L. Roberts, Yong-Jie Zhou, Min Chen, Massimo Gadina, Nancy Cusack, Kelly S. Magnuson, Wen Lin, Robert L. Geahlen, Lida H. Kimmel, James G. Boyd

Publikováno v: Molecular Cell. 8(5):959-969

Janus kinases comprise carboxyterminal kinase, pseudokinase, SH2-like, and N-terminal FERM domains. We identified three patient-derived mutations in the FERM domain of Jak3 and investigated the functional consequences of these mutations. These mutati

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The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals

Autor: Alan C. Cheng, Tadatsugu Taniguchi, Lida H. Kimmel, Anka Hymel, Eric P. Hanson, Paul S. Changelian, Yasuhiro Minami, Min Chen, Yi-Qing Chen, John J. O'Shea

Publikováno v: Proceedings of the National Academy of Sciences. 94:6910-6915

JAK3 is a protein tyrosine kinase that specifically associates with the common γ chain (γc), a shared subunit of receptors for interleukin (IL) 2, 4, 7, 9, and 15. Patients deficient in either JAK3 or γcpresented with virtually identical forms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa85aac1de0b25e33b430328c71b25ac
https://doi.org/10.1073/pnas.94.13.6910

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Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease

Autor: Alison Romegialli, Max Kuhn, Christopher J. Schmidt, Kenneth S Miller, Shelley G. des Etages, Susan E. Bove, Amy Willis, John F. Harms, Lida H. Kimmel, Robin J. Kleiman, Thomas A. Lanz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 336(1)

Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1da8e1ee5d6cde991692e953a75405
https://pubmed.ncbi.nlm.nih.gov/20923867

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P1‐337: Overexpression of human tau induces loss of synaptic markers and requires phosphorylation of tau in the microtubule binding domain

Autor: Tracy M. Brown, Lida H. Kimmel, Carol D. Hicks, Paula Loos, Karl E.G. Richter, Robin J. Kleiman

Publikováno v: Alzheimer's & Dementia. 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::646c9b1313636fab5c343e5dd74dfd91
https://doi.org/10.1016/j.jalz.2010.05.890

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Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele

Autor: John J. Bartko, Karen Putnam, Holly Soares, Judy Bergeson, Robert M. Cohen, Gyorgy Csako, Gary Linker, James A. Levy, Trey Sunderland, Rob Durham, Lida H. Kimmel, Nadeem Mirza, Deepa Bhupali, David L. Friedman

Publikováno v: Biological psychiatry. 56(9)

Cerebrospinal fluid (CSF) measures of beta-amyloid(1-42) and tau are linked with the known neuropathology of Alzheimer's disease (AD). Numerous lines of evidence have also suggested that individuals with at least one APOE epsilon4 allele on chromosom

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https://pubmed.ncbi.nlm.nih.gov/15522251

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Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease

Autor: David L. Friedman, Guy J. Manetti, Lida H. Kimmel, Judy Bergeson, Brian Tang, Matthew Zimmermann, Karen Putnam, Trey Sunderland, John J. Bartko, Robert M. Cohen, Gary Linker, Nadeem Mirza

Publikováno v: JAMA. 289

ContextAlzheimer disease (AD) is characterized by pathological results at autopsy of amyloid plaques and tau-associated neurofibrillary tangles, but the clinical diagnosis of AD is determined on the basis of medical history, cognitive symptoms, and e

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https://doi.org/10.1001/jama.289.16.2094

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Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion

Autor: Diana G. Myles, Lida H. Kimmel, Paul Primakoff, Judith M. White, Carl P. Blobel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 91(10)

Fertilization and certain later stages in mammalian embryonic development require fusion between membranes of individual cells. The mechanism of eukaryotic cell-cell fusion is unknown, and no surface molecules required for this process have been uneq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf493d44ca6cf46eb3eb5e050ea6dc5
https://pubmed.ncbi.nlm.nih.gov/8183890

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Molecular cloning of the human and monkey sperm surface protein PH-20

Autor: Paul Primakoff, Lida H. Kimmel, Ying Lin, Diana G. Myles

The guinea pig sperm surface protein PH-20 has an essential function in sperm adhesion to the zona pellucida of guinea pig eggs. Fully effective contraception has been achieved by immunizing either male or female guinea pigs with purified guinea pig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bad8780155be394c4d62d03501430ae
https://europepmc.org/articles/PMC47715/

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Inhibitors of cAMP and cGMP phosphodiesterases enhance neurite outgrowth from cultured cortical neurons in a PKG dependent manner

Autor: Frank S. Menniti, Christopher J. Schmidt, Mary Collins, Lida H. Kimmel, Robin J. Kleiman

Publikováno v: BMC Pharmacology. 7(Suppl 1):P33

Cyclic nucleotide signalling plays a key role in regulating neurite outgrowth in developmental and injury settings. The functional consequences of enhanced cyclic nucleotide signalling on processes that contribute to neurite outgrowth varies across n

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