Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade

Autor: Lisowska, Małgorzata, Lickiss, Fiona, Gil-Mir, Maria, Huart, Anne-Sophie, Trybala, Zuzanna, Way, Luke, Hernychova, Lenka, Krejci, Adam, Muller, Petr, Krejcir, Radovan, Zhukow, Igor, Jurczak, Przemyslaw, Rodziewicz-Motowidło, Sylwia, Ball, Kathryn, Vojtesek, Borivoj, Hupp, Ted, Kalathiya, Umesh

Publikováno v: Lisowska, M, Lickiss, F, Gil-mir, M, Huart, A, Trybala, Z, Way, L, Hernychova, L, Krejci, A, Muller, P, Krejcir, R, Zhukow, I, Jurczak, P, Rodziewicz-motowidło, S, Ball, K, Vojtesek, B, Hupp, T & Kalathiya, U 2022, ' Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade ', Frontiers in Microbiology, vol. 13 . https://doi.org/10.3389/fmicb.2022.875556

Defining dynamic protein–protein interactions in the ubiquitin conjugationreaction is a challenging research area. Generating peptide aptamers thattarget components such as ubiquitin itself, E1, E2, or E3 could provide toolsto dissect novel feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac439f3d6d2a407caf2c5b61c98a754
https://www.pure.ed.ac.uk/ws/files/312917548/Next_generation_sequencing_of_a_combinatorial_peptide_phage_library_screened_against_ubiquitin_identifies_peptide_aptamers_that_can_inhibit_the_in_vitro_ubiquitin_transfer_cascade.pdf

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival.

Autor: Shboul, Sofian Al, Curran, Olimpia E., Alfaro, Javier A., Lickiss, Fiona, Nita, Erisa, Kowalski, Jacek, Naji, Faris, Nenutil, Rudolf, Ball, Kathryn L., Krejcir, Radovan, Vojtesek, Borivoj, Hupp, Ted R., Brennan, Paul M.

Publikováno v: Life Science Alliance; Dec2021, Vol. 4 Issue 12, p1-19, 19p

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival.

Autor: Al Shboul S; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK s.alshboul@ed.ac.uk.; Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan., Curran OE; Department of Neuropathology, Western General Hospital, Edinburgh, UK.; Cardiff University Hospital, Cellular Pathology, Cardiff, UK., Alfaro JA; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland., Lickiss F; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland., Nita E; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Kowalski J; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland., Naji F; Pamgene International BV, 's-Hertogenbosch, Netherlands., Nenutil R; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Ball KL; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Krejcir R; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Vojtesek B; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Hupp TR; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland., Brennan PM; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK paul.brennan@ed.ac.uk.; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Publikováno v: Life science alliance [Life Sci Alliance] 2021 Oct 13; Vol. 4 (12). Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2021).