Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade

Autor: Lisowska, Małgorzata, Lickiss, Fiona, Gil-Mir, Maria, Huart, Anne-Sophie, Trybala, Zuzanna, Way, Luke, Hernychova, Lenka, Krejci, Adam, Muller, Petr, Krejcir, Radovan, Zhukow, Igor, Jurczak, Przemyslaw, Rodziewicz-Motowidło, Sylwia, Ball, Kathryn, Vojtesek, Borivoj, Hupp, Ted, Kalathiya, Umesh

Publikováno v: Lisowska, M, Lickiss, F, Gil-mir, M, Huart, A, Trybala, Z, Way, L, Hernychova, L, Krejci, A, Muller, P, Krejcir, R, Zhukow, I, Jurczak, P, Rodziewicz-motowidło, S, Ball, K, Vojtesek, B, Hupp, T & Kalathiya, U 2022, ' Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade ', Frontiers in Microbiology, vol. 13 . https://doi.org/10.3389/fmicb.2022.875556

Defining dynamic protein–protein interactions in the ubiquitin conjugationreaction is a challenging research area. Generating peptide aptamers thattarget components such as ubiquitin itself, E1, E2, or E3 could provide toolsto dissect novel feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac439f3d6d2a407caf2c5b61c98a754
https://www.pure.ed.ac.uk/ws/files/312917548/Next_generation_sequencing_of_a_combinatorial_peptide_phage_library_screened_against_ubiquitin_identifies_peptide_aptamers_that_can_inhibit_the_in_vitro_ubiquitin_transfer_cascade.pdf

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival.

Autor: Shboul, Sofian Al, Curran, Olimpia E., Alfaro, Javier A., Lickiss, Fiona, Nita, Erisa, Kowalski, Jacek, Naji, Faris, Nenutil, Rudolf, Ball, Kathryn L., Krejcir, Radovan, Vojtesek, Borivoj, Hupp, Ted R., Brennan, Paul M.

Publikováno v: Life Science Alliance; Dec2021, Vol. 4 Issue 12, p1-19, 19p

The role of the RING domain in MDM2-mediated ubiquitination of p53

Autor: Lickiss, Fiona Rachael

The MDM2 protein regulates the tumour suppressor protein p53, acting as its chaperone, regulating its translation and targeting p53 for degradation by the 26s proteasome via its E3 ligase activity. The E3 ligase activity of MDM2 is dependent on its C

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712291