Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Licia Tomei"'
Autor:
Shiyu Xu, Gang Li, Xin Ye, Dongsheng Chen, Zhihua Chen, Zhen Xu, Moretti Daniele, Sara Tambone, Alessandra Ceccacci, Licia Tomei, Lili Ye, Yue Yu, Amanda Solbach, Stephen M. Farmer, Erin Furr Stimming, George McAllister, Deanna M. Marchionini, Sheng Zhang
Publikováno v:
PLoS Genetics, Vol 18, Iss 7 (2022)
Perturbation of huntingtin (HTT)’s physiological function is one postulated pathogenic factor in Huntington’s disease (HD). However, little is known how HTT is regulated in vivo. In a proteomic study, we isolated a novel ~40kDa protein as a stron
Externí odkaz:
https://doaj.org/article/c7360dc9b466498b894ef2ac0e70a9a8
Autor:
Christopher Ullman, Pascale Mathonet, Arkadiusz Oleksy, Agata Diamandakis, Licia Tomei, Anna Demartis, Chiara Nardi, Sonia Sambucini, Antonino Missineo, Karen Alt, Christoph E Hagemeyer, Matt Harris, Amos Hedt, Roland Weis, Kurt R Gehlsen
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135278 (2015)
Abdurins are a novel antibody-like scaffold derived from the engineering of a single isolated CH2 domain of human IgG. Previous studies established the prolonged serum half-life of Abdurins, the result of a retained FcRn binding motif. Here we presen
Externí odkaz:
https://doaj.org/article/3a073bcf76034792bae6d8359be7390a
Autor:
Stefania Colarusso, Federica Ferrigno, Simona Ponzi, Francesca Pavone, Immacolata Conte, Luigi Abate, Elisa Beghetto, Antonino Missineo, Jerome Amaudrut, Alberto Bresciani, Giacomo Paonessa, Licia Tomei, Christian Montalbetti, Elisabetta Bianchi, Carlo Toniatti, Jesus M. Ontoria
Publikováno v:
Bioorganicmedicinal chemistry. 57
Zika virus (ZIKV) is a member of the Flaviviridae family that can cause neurological disorders and congenital malformations. The NS2B-NS3 viral serine protease is an attractive target for the development of new antiviral agents against ZIKV. We repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0680820a0134a770bbd82b788e7dda5a
https://pubmed.ncbi.nlm.nih.gov/35123179
https://pubmed.ncbi.nlm.nih.gov/35123179
Autor:
Paola Fezzardi, Steven J. Harper, Alberto Bresciani, Licia Tomei, Leticia-Toledo Sherman, Ignacio Munoz-Sajuan, Larry Park, Antonino Missineo, Mauro Cerretani, Robert Pacifici, Celia Dominquez, Daniele Moretti, Sara Tambone
Publikováno v:
Free radical biologymedicine. 162
Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a mutation in the huntingtin gene. Oxidative stress induced reactive oxygen species (ROS) are norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c125dfcb529779046473cfcc08c87c5
https://pubmed.ncbi.nlm.nih.gov/33096251
https://pubmed.ncbi.nlm.nih.gov/33096251
Autor:
Licia Tomei, Antonino Missineo, Ottavia Cecchetti, Pier Giorgio Pacifici, Alberto Bresciani, Steven Rodems
Publikováno v:
SLAS Discovery. 23:941-950
Glycosylation is a key posttranslational modification that tags protein to membranes, organelles, secretory pathways, and degradation. Aberrant protein glycosylation is present both in acquired diseases, such as cancer and neurodegeneration, and in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3523fd964e83b17a675830bbc4c46444
https://doi.org/10.1177/2472555218782625
https://doi.org/10.1177/2472555218782625
Autor:
Federica Orvieto, Antonello Pessi, Brian Hawes, Paul E. Carrington, Licia Tomei, Armin Lahm, Sheena Mumick, Anandan Palani, Francesco Frattolillo, Valentina Di Biasio, Elisabetta Bianchi, Anna Demartis, Elisa Beghetto
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
A promising emerging area for the treatment of obesity and diabetes is combinatorial hormone therapy, where single-molecule peptides are rationally designed to integrate the complementary actions of multiple endogenous metabolically-related hormones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c37e0ac29fd7f3dd742cc540e3d889d
http://link.springer.com/article/10.1038/s41598-017-18494-5
http://link.springer.com/article/10.1038/s41598-017-18494-5
Autor:
Daniel O. Cicero, Elisabetta Bianchi, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan, Paola Fezzardi, Licia Tomei, Robert Pacifici, Alessia Santoprete, Alberto Bresciani, Celia Dominguez, Antonino Missineo, Larry Park, Raffaele Ingenito, Mauro Cerretani, Sergio Altamura, Steven J. Harper, Mariana Gallo
Publikováno v:
Archives of Biochemistry and Biophysics. 631:31-41
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in diseases, such as Parkinson's disease, Alzheimer's disease and Huntington's disease, where the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23111e296eb4dd845228e78fe4f9832e
https://doi.org/10.1016/j.abb.2017.08.003
https://doi.org/10.1016/j.abb.2017.08.003
Autor:
Matteo Andreini, Stefan Steinbacher, Antonino Missineo, Georg Kempf, Ignacio Munoz-Sanjuan, Licia Tomei, Vincenzo Summa, Tommaso Frattarelli, D. De Simone, Mauro Cerretani, Leticia Toledo-Sherman, Celia Dominguez, Martin Augustin, Elisabetta Bianchi, Daniele Moretti, Sara Tambone, Stefania Colarusso, Larry Park, Alberto Bresciani
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115738
Inhibition of KEAP1-NRF2 protein-protein interaction is considered a promising strategy to selectively and effectively activate NRF2, a transcription factor which is involved in several pathologies such as Huntington's disease (HD). A library of line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489702ad5ac860849caf323775f152eb
https://doi.org/10.1016/j.bmc.2020.115738
https://doi.org/10.1016/j.bmc.2020.115738
Autor:
Frank Narjes, Barbara Pacini, Laura Pacini, Salvatore Avolio, Giovanni Migliaccio, Licia Tomei, Caterina Ercolani, Uwe Koch, Steven Harper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6245-6249
A series of 2-(3-thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acid inhibitors of the hepatitis C virus (HCV) NS5B polymerase enzyme are reported. Sulfonyl urea substituted analogs in this series proved to be the most potent active site non-nucleosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f53da323661e185bf15bb6b8b896a4b
https://doi.org/10.1016/j.bmcl.2009.06.106
https://doi.org/10.1016/j.bmcl.2009.06.106
Publikováno v:
ELECTROPHORESIS. 30:2469-2476
The protein tyrosine phosphatase PRL-3 is an appealing therapeutic cancer target for its well described involvement in the metastasis progression. Nevertheless, very little is known about PRL-3 role in tumorigenesis. In the attempt to identify the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19185d159c8fcf33ccd771ad8def260
https://doi.org/10.1002/elps.200800780
https://doi.org/10.1002/elps.200800780