Mutational landscape of patients with acute promyelocytic leukemia at diagnosis and relapse

Autor: Giulia Falconi, Maria Teresa Voso, Torsten Haferlach, Tiziana Ottone, Laura Cicconi, Francesco Lo-Coco, William Arcese, Serena Travaglini, Maria Ilaria Del Principe, Constance Baer, Monica Usai, Serena Lavorgna, Valentina Alfonso, Licia Iaccarino, Adriano Venditti, Fabio Forghieri, Mariadomenica Divona, Aleandra Ferrantini

Publikováno v: American Journal of Hematology. 94:1091-1097

Despite the high probability of cure of patients with acute promyelocytic leukemia (APL), mechanisms of relapse are still largely unclear. Mutational profiling at diagnosis and/or relapse may help to identify APL patients needing frequent molecular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86700eb94bf7b1a8da17a0f91369ef4
https://doi.org/10.1002/ajh.25573

Prolonged treatment with arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA) for relapsed acute promyelocytic leukemia previously treated with ATRA and chemotherapy

Autor: Tiziana Ottone, Daniela Diverio, Robin Foà, Maria Teresa Voso, Valentina Alfonso, Massimo Breccia, Laura Cicconi, Roberto Latagliata, Luca Franceschini, Matteo Molica, Manuela Rizzo, Licia Iaccarino, Francesco Lo-Coco, Mariadomenica Divona

Publikováno v: Annals of Hematology. 97:1797-1802

Prolonged therapy with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) is highly effective in newly diagnosed acute promyelocytic leukemia (APL) but there is limited data on the efficacy of this regimen in the relapse setting. We report her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54088988aa3c14db66ed6600e946685
https://doi.org/10.1007/s00277-018-3400-z

Identification and monitoring of atypical PML/RARA fusion transcripts in acute promyelocytic leukemia

Autor: Laura Cicconi, Francesco Lo-Coco, Giuseppe Cimino, Mariadomenica Divona, Valentina Alfonso, Eros Di Bona, Licia Iaccarino, Serena Travaglini, Luca Facchini, Maria Teresa Voso, Tiziana Ottone, Serena Lavorgna, Claudia Ciardi

Publikováno v: Genes, chromosomescancer. 58(1)

Once the diagnostic suspicion of acute promyelocytic leukemia (APL) has been raised, international guidelines recommend prompt initiation of tailored therapy and supportive care, while awaiting for genetic confirmation of the diagnosis, and the ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52cc8ba3660864db67de2d66d91e737
https://pubmed.ncbi.nlm.nih.gov/30421475

Comparative genomic analysis of PML and RARA breakpoints in paired diagnosis/relapse samples of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy

Autor: Mariadomenica Divona, Francesco Lo-Coco, Laura Cicconi, David Grimwade, Giuseppe Basso, Eva Barragán, Eduardo Magalhães Rego, Monica Bocchia, Maria Teresa Voso, Serena Lavorgna, Valentina Alfonso, Syed Khizer Hasan, Licia Iaccarino, Tiziana Ottone

Publikováno v: Leukemia & lymphoma
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the PML/RARA ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52020eda2a57c5b62ea822f72a95a85c
http://hdl.handle.net/2108/187797

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