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Akademický článek

Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling

Autor: Lichun Weng, Hanqing Hong, Qinyu Zhang, Chengqi Xiao, Qiuwan Zhang, Qian Wang, Ju Huang, Dongmei Lai

Publikováno v: Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)

Abstract Sleep deprivation (SD) is observed to adversely affect the reproductive health of women. However, its precise physiological mechanisms remain largely elusive. In this study, using a mouse model of SD, it is demonstrated that SD induces the d

Externí odkaz: https://doaj.org/article/14daaabd65a74415a377e74cb511d5c8

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Akademický článek

Safety and efficacy of allogenic human amniotic epithelial cells transplantation via ovarian artery in patients with premature ovarian failure: a single-arm, phase 1 clinical trialResearch in context

Autor: Lichun Weng, Liutong Wei, Qiuwan Zhang, Taotao Sun, Xiaojun Kuang, Qin Huang, Yunyun Cao, Xiaoyi Liu, Qian Wang, Ying Guo, Junyan Sun, Lulu Wang, Haihong Tang, Haiou Yang, Qian Chen, Jian Zhang, Bingshun Wang, Zhaoxia Qian, Dongmei Lai

Publikováno v: EClinicalMedicine, Vol 74, Iss , Pp 102744- (2024)

Summary: Background: Premature ovarian failure (POF) is a prevalent and severe condition that impairs female health but there is currently no effective treatment available to restore ovarian function. Human amniotic epithelial cells (hAECs) exhibit o

Externí odkaz: https://doaj.org/article/390555fe44fb4abb8d43e7ccbb40a2da

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Akademický článek

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells.

Autor: Lin Hou, Hanqing Hong, Wenjiao Cao, Liutong Wei, Lichun Weng, Shuang Yuan, Chengqi Xiao, Qiuwan Zhang, Qian Wang, Dongmei Lai

Publikováno v: Acta Biochimica et Biophysica Sinica; Feb2024, Vol. 56 Issue 2, p239-254, 16p

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Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16− NK-cell differentiation

Autor: Haiyan Peng, Lichun Weng, Shating Lei, Shuhui Hou, Shaoliang Yang, Mingqing Li, Dong Zhao

Publikováno v: Experimental & Molecular Medicine. 54:890-905

Prostacyclin (PGI2) plays key roles in shaping the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacyclin synthase (PTGIS)-dependent PGI2 sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82bad42809e8fd0db79aac0ae0219d73
https://doi.org/10.1038/s12276-022-00793-1

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Downregulating HK2 inhibits proliferation of endometrial stromal cells through a noncanonical pathway involving phosphorylation of signal transducer and activator of transcription 1 in endometriosis

Autor: Shuhui, Hou, Shating, Lei, Haiyan, Peng, Lichun, Weng, Siji, Lv, Mingqing, Li, Dong, Zhao

Publikováno v: Biology of Reproduction. 107:488-499

Background Endometriosis is a benign gynecologic disease that causes chronic pelvic pain, dysmenorrhea and infertility and shares several characteristics with malignant tumors, afflicting women of reproductive age. Hexokinase 2 plays an essential rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e51e1081d0d9c3e3059ebb968b6019
https://doi.org/10.1093/biolre/ioac081

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YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A

Autor: Ling Hong, Haili Gan, Lichun Weng, Qingliang Zheng, Xiaowen Pu

Publikováno v: Journal of Cancer. 12:3809-3818

RNA epigenetic modification take part in many biology processes, and the N6-methyladenosine (m6A) methylation of specific mRNAs in endometrial cancer (EC) tissues play a key role in regulating the tumorigenicity of EC, but the specific mechanism stil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39a884b48508d177a7e821ca8429d2ed
https://doi.org/10.7150/jca.54527

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