Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lichuan Bai"'
Autor:
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao
Publikováno v:
Journal of Advanced Research, Vol 33, Iss , Pp 253-264 (2021)
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis. However, whether TMEM16A contributes to breast cancer metastasis remains unkno
Externí odkaz:
https://doaj.org/article/b3e2da5b41634b68aa0b5c36e8f4be76
Autor:
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao
Publikováno v:
Journal of Advanced Research, Vol 29, Iss , Pp 23-32 (2021)
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension. It remains unclear whether TMEM16A regulates end
Externí odkaz:
https://doaj.org/article/c9dfec59d8c14f548c7581916644aa7a
Autor:
Qinghua Wang, Lichuan Bai, Shuya Luo, Tianyu Wang, Fan Yang, Jialin Xia, Hui Wang, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Shibin Guo, Xiaohong Sun, Qinghuan Xiao
Publikováno v:
Journal of Advanced Research, Vol 23, Iss , Pp 25-35 (2020)
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown. Here, we found that increa
Externí odkaz:
https://doaj.org/article/4d5f68e73c084ab78e91f860f73702f7
Autor:
Qinghuan Xiao, Ke Ma, Shuya Luo, Yue Fang, Hui Wang, Mei Liu, Hanbin Song, Kuan Gao, Huijie Wang, Lichuan Bai, Si Chen, Yiwen Chen, Shuwei Wu, Fan Yao
Publikováno v:
Journal of Advanced Research, Vol 33, Iss, Pp 253-264 (2021)
Introduction Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis. However, whether TMEM16A contributes to breast cancer metastasis remains unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2493cd4b6ad217e351e6b0ed25c58e1f
https://doi.org/10.1016/j.jare.2021.03.005
https://doi.org/10.1016/j.jare.2021.03.005
Autor:
Shuwei Wu, Shuya Luo, Zaixing Chen, Mei Liu, Lichuan Bai, Tianyu Wang, Qinghuan Xiao, Ke Ma, Hui Wang, Huijie Wang, Fan Yang, Kuan Gao
Publikováno v:
British Journal of Pharmacology. 178:4137-4154
BACKGROUND AND PURPOSE Ca2+ -activated Cl- channels (Ano1 channels) contribute to the pathogenesis of colorectal cancer. Honokiol is known to inhibit cell proliferation and tumour growth in colorectal cancer. However, the molecular target of honokiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43609eb5b4e8529781354e21357c6f2
https://doi.org/10.1111/bph.15606
https://doi.org/10.1111/bph.15606
Autor:
Shuya Luo, Lichuan Bai, Guan Wang, Sitong Liu, Hui Wang, Qinghuan Xiao, Ke Ma, Tianyu Wang, Kuan Gao, Hongyue Liang, Mei Liu
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 29, Iss, Pp 23-32 (2021)
Journal of Advanced Research, Vol 29, Iss, Pp 23-32 (2021)
Graphical abstract Cholesterol reduces TMEM16A expression via DNMT1-mediated promoter methylation and directly inhibits channel activities. TMEM16A inhibition promotes endothelial angiogenesis.
Introduction Ca2+-activated Cl− channel TMEM16A i
Introduction Ca2+-activated Cl− channel TMEM16A i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c199e8fb29bfa734f960b1e2a8383f5
http://europepmc.org/articles/PMC8020148
http://europepmc.org/articles/PMC8020148
Autor:
Shuya Luo, Lichuan Bai, Qinghua Wang, Mei Liu, Huijie Wang, Jialin Xia, Qinghuan Xiao, Ke Ma, Shuwei Wu, Tianyu Wang, Shibin Guo, Fan Yang, Xiaohong Sun, Hui Wang
Publikováno v:
Journal of Advanced Research, Vol 23, Iss, Pp 25-35 (2020)
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown. Here, we found that increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a407e385e8970c26ccfe957c015c457
http://www.sciencedirect.com/science/article/pii/S2090123220300060
http://www.sciencedirect.com/science/article/pii/S2090123220300060
Autor:
Tianyu, Wang, Hui, Wang, Fan, Yang, Kuan, Gao, Shuya, Luo, Lichuan, Bai, Ke, Ma, Mei, Liu, Shuwei, Wu, Huijie, Wang, Zaixing, Chen, Qinghuan, Xiao
Publikováno v:
British journal of pharmacologyREFERENCES. 178(20)
CaPatch-clamp techniques were performed to study the effect of honokiol on CaHonokiol blocked Ano1 currents in Ano1-overexpressing HEK293 cells and SW620 cells. Honokiol more potently inhibited Ano1 currents than Ano2 currents. Three amino acids (R42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1785623ecc469365147b82bde6540a41
https://pubmed.ncbi.nlm.nih.gov/34192810
https://pubmed.ncbi.nlm.nih.gov/34192810
Autor:
Shuya, Luo, Hui, Wang, Lichuan, Bai, Yiwen, Chen, Si, Chen, Kuan, Gao, Huijie, Wang, Shuwei, Wu, Hanbin, Song, Ke, Ma, Mei, Liu, Fan, Yao, Yue, Fang, Qinghuan, Xiao
Publikováno v:
Journal of Advanced Research
Graphical abstract Increased TMEM16A channel activities activate EGFR/STAT3/ROCK1 signaling, and ROCK1 activation by RhoA increased TMEM16A channel activities via moesin phosphorylation at T558. TMEM16A and ROCK1/moesin signaling cooperatively promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fa8886521edb0511d17459f07755919
https://pubmed.ncbi.nlm.nih.gov/34603794
https://pubmed.ncbi.nlm.nih.gov/34603794
Autor:
Qinghua, Wang, Lichuan, Bai, Shuya, Luo, Tianyu, Wang, Fan, Yang, Jialin, Xia, Hui, Wang, Ke, Ma, Mei, Liu, Shuwei, Wu, Huijie, Wang, Shibin, Guo, Xiaohong, Sun, Qinghuan, Xiao
Publikováno v:
Journal of Advanced Research
Graphical abstract A positive activation loop between TMEM16A and the IP3R/Ca2+/NFκB/IL-6 pathway is important for Ca2+ elevation, NFκB activation and IL-6 release, and thus cooperatively promotes the pathogenesis of AP.
TMEM16A Ca2+-activated
TMEM16A Ca2+-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2a3e77ba7ea409a56ae2bf0b475cc7c
https://pubmed.ncbi.nlm.nih.gov/32071789
https://pubmed.ncbi.nlm.nih.gov/32071789