Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lichong SHEN"'
Autor:
Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen, Qingran Yan
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized anti-rheumatic disease-modifying drug, which shows drastic inhibition to EGR1 expr
Externí odkaz:
https://doaj.org/article/8dcedb4e508e4234a87abe795a9d4229
Autor:
Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen, Qingran Yan
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/945f3cf7e0564b009616808dcbca857e
Autor:
Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patient
Externí odkaz:
https://doaj.org/article/62b5d5ace81c405bb445c8cf7e9725a7
Publikováno v:
Archives of Rheumatology. Jun2020, Vol. 35 Issue 2, p180-188. 9p. 2 Charts, 1 Graph.
Autor:
Julia Winkler, Andreas Mackensen, Jörg H W Distler, Clara Dees, Xianyi Meng, Andreas Beilhack, Wolfgang Herr, Honglin Zhu, Cuong Tran-Manh, Thuong Trinh-Minh, Katja Dreißigacker, Mirjana Ziemer, Yun Zhang, Bernd M. Spriewald, Chih-Wei Chen, Alexandru-Emil Matei, Sigrid Karrer, Daniel Wolff, Georg Schett, Lichong Shen, Markus Ditschkowski, Stefan Krauss
Publikováno v:
Blood. 137:2403-2416
Chronic graft-versus-host disease (cGVHD) is a major life-threatening complication of allogeneic hematopoietic stem cell transplantation. The molecular mechanisms underlying cGVHD remain poorly understood, and targeted therapies for clinical use are
Publikováno v:
Arch Rheumatol
Objectives This study reports a low dose combination therapy of cyclophosphamide (CYC) and pirfenidone (PFD) and the efficiency and safety of the therapy in refractory connective tissue disease associated interstitial lung disease (CTD-ILD) patients.
Autor:
Ariella, Zehender, Yi-Nan, Li, Neng-Yu, Lin, Adrian, Stefanica, Julian, Nüchel, Chih-Wei, Chen, Hsiao-Han, Hsu, Honglin, Zhu, Xiao, Ding, Jingang, Huang, Lichong, Shen, Andrea-Hermina, Györfi, Alina, Soare, Simon, Rauber, Christina, Bergmann, Andreas, Ramming, Markus, Plomann, Beate, Eckes, Georg, Schett, Jörg H W, Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several pathways capable of promoting fibroblast activation and tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::574afd08ae48f2b3043984f58e323446
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/19463
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/19463
Autor:
Diana Distler, Andrea Hermina Györfi, Ingo Ludolph, Yun Zhang, Jörg H W Distler, Katja Dreissigacker, Thuong Trinh-Minh, Xiang Zhou, Xianyi Meng, Clara Dees, Andreas Ramming, Raymund E. Horch, Lichong Shen, Honglin Zhu, Christina Bergmann, Georg Schett
Publikováno v:
Annals of the rheumatic diseases. 79(9)
ObjectivesCoactivators are a heterogeneous family of transcriptional regulators that are essential for modulation of transcriptional outcomes and fine-tune numerous cellular processes. The aim of the present study was to evaluate the role of the coac
Autor:
Lichong Shen
Publikováno v:
Archives of Rheumatology. 35
Publikováno v:
Abstracts accepted for Publication.
Background There are anti-inflammation and anti-fibrosis agents available for connective tissue disease associated interstitial lung disease (CTD-ILD). A clinical study has been initiated to assess the combination of the two (NCT03221257), but whethe