Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Lichen Jing"'
Autor:
Anuradha Sooda, Francois Rwandamuriye, Celestine N. Wanjalla, Lichen Jing, David M. Koelle, Bjoern Peters, Shay Leary, Abha Chopra, Michael A. Calderwood, Simon A. Mallal, Rebecca Pavlos, Mark Watson, Elizabeth J. Phillips, Alec J. Redwood
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
HLA-B*57:01 restricted EBV-specific T-cell receptor specificity is altered by abacavir, suggesting a potentially inhibitory effect of abacavir on HLA-B*57:01 restricted TCR recognition.
Externí odkaz:
https://doaj.org/article/bcdd7ff4c80c420a8da2e27c19a3a258
Autor:
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid antigens
Externí odkaz:
https://doaj.org/article/5ffbba8ac40b4631bfdd4ca36548cb97
Autor:
Vladimir Makarov, Paul Nghiem, Jaehyuk Choi, Timothy A Chan, Kimberly S Smythe, Jean S Campbell, Robert H Pierce, Raphael Gottardo, Candice Church, David M Koelle, Thomas Pulliam, Natalie Longino, Song Y Park, Nadeem Riaz, Lichen Jing, Robert Amezquita
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade, regardless of tumor-viral status (~80% of cases driven by the Merkel cell polyomavirus (MCPyV)). Prior studies have characterized tumor-specific T cell responses to MCPyV
Externí odkaz:
https://doaj.org/article/5ad5aa1d8a2c41f09cc92ec9ecc890fa
Autor:
Rebecca Elyanow, Thomas M. Snyder, Sudeb C. Dalai, Rachel M. Gittelman, Jim Boonyaratanakornkit, Anna Wald, Stacy Selke, Mark H. Wener, Chihiro Morishima, Alexander L. Greninger, Michael Gale Jr., Tien-Ying Hsiang, Lichen Jing, Michael R. Holbrook, Ian M. Kaplan, H. Jabran Zahid, Damon H. May, Jonathan M. Carlson, Lance Baldo, Thomas Manley, Harlan S. Robins, David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell responses, but these responses vary with disease severity and individual characterist
Externí odkaz:
https://doaj.org/article/c720e1a7f2ea4a9bb6e8db6d06e7b8ab
Autor:
Lichen Jing, Xia Wu, Maxwell P. Krist, Tien-Ying Hsiang, Victoria L. Campbell, Christopher L. McClurkan, Sydney M. Favors, Lawrence A. Hemingway, Charmie Godornes, Denise Q. Tong, Stacy Selke, Angela C. LeClair, Chu-Woo Pyo, Daniel E. Geraghty, Kerry J. Laing, Anna Wald, Michael Gale Jr., David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-
Externí odkaz:
https://doaj.org/article/ac5bab028d2c47d8a3ac6df92bba3c0e
Autor:
David M. Koelle, Lichun Dong, Lichen Jing, Kerry J. Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M. Posavad
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antigen-specific TRM persist and protect against skin or female reproductive tract (FRT) HSV infection. As the pathogenesis of HSV differs between humans and model organisms, we focus on humans with well-characterized recurrent genital HSV-2 infectio
Externí odkaz:
https://doaj.org/article/d4460575337543f2912b8830e07cda91
Autor:
Tao Peng, Khamsone Phasouk, Catherine N. Sodroski, Sijie Sun, Yon Hwangbo, Erik D. Layton, Lei Jin, Alexis Klock, Kurt Diem, Amalia S. Magaret, Lichen Jing, Kerry Laing, Alvason Li, Meei-Li Huang, Max Mertens, Christine Johnston, Keith R. Jerome, David M. Koelle, Anna Wald, David M. Knipe, Lawrence Corey, Jia Zhu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tissue-resident-memory T cells (TRM) populate the body’s barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete i
Externí odkaz:
https://doaj.org/article/8a1eece0c94043338e4530333d1db25a
Autor:
Dallas Jones, Christina N Como, Lichen Jing, Anna Blackmon, Charles Preston Neff, Owen Krueger, Andrew N Bubak, Brent E Palmer, David M Koelle, Maria A Nagel
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007650 (2019)
Varicella zoster virus (VZV) is a lymphotropic alpha-herpesvirinae subfamily member that produces varicella on primary infection and causes zoster, vascular disease and vision loss upon reactivation from latency. VZV-infected peripheral blood mononuc
Externí odkaz:
https://doaj.org/article/6b02d1429cd24b348ec9a9a397bd3783
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Infection and vaccination can lead to activation of autoreactive T cells, including the activation of cross-reactive T cells. However, detecting these cross-reactive T cells and identifying the non-self and self-antigen epitopes is difficult. The cur
Externí odkaz:
https://doaj.org/article/b85554ace8cf44c28a3677f410084407
Autor:
Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, Nina Derby
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Herpes simplex virus 1 and 2 (HSV-1/2) similarly initiate infection in mucosal epithelia and establish lifelong neuronal latency. Anogenital HSV-2 infection augments the risk for sexual human immunodeficiency virus (HIV) transmission and is associate
Externí odkaz:
https://doaj.org/article/1f673356d51b44bbb4efd3d67140f2ad