Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lichen Bao"'
Publikováno v:
Molecules, Vol 28, Iss 3, p 1337 (2023)
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquitin-like modi
Externí odkaz:
https://doaj.org/article/1098785243254311b20f8874db040baf
Publikováno v:
Acta Biomaterialia. 164:74-93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d8c6b1e3c2d7bb1999e0584874e6bd
https://doi.org/10.1016/j.actbio.2023.04.019
https://doi.org/10.1016/j.actbio.2023.04.019
Publikováno v:
Journal of Controlled Release. 346:250-259
Multidrug resistance (MDR) to chemotherapeutic drugs and targeted drug delivery are recurring issues in clinical cancer treatment. Here, a multifunctional fusion protein-DNA conjugate was designed as a co-delivery vehicle for anticancer peptides and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b117833f5e515450533f31d2986affb
https://doi.org/10.1016/j.jconrel.2022.04.022
https://doi.org/10.1016/j.jconrel.2022.04.022
Autor:
Dingkang Liu, Chen Ye, Qun Wang, Jun Yin, Shan Hou, Lichen Bao, Xiangdong Gao, Wenbing Yao, Yali Yue
Publikováno v:
Cancer Letters. 452:38-50
The great therapeutic potential of peptides has not yet been achieved, mainly due to their remarkably short in vivo half-life. Although conjugation to macromolecules has been an effective way of improving protein in vivo half-life, the steric hindran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ace9c993d11afac85b593b6d2e8b05
https://doi.org/10.1016/j.canlet.2019.03.016
https://doi.org/10.1016/j.canlet.2019.03.016
Publikováno v:
British Journal of Pharmacology. 175:3379-3393
Background and purpose Non-alcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world. There are currently no approved treatments for NASH. FGF21 has recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b07b1da756d865ac5289a055a96db5
https://doi.org/10.1111/bph.14383
https://doi.org/10.1111/bph.14383
Publikováno v:
ACS Synthetic Biology. 7:1291-1302
Escherichia coli extracellular expression systems have a number of advantages over other systems, such as lower pyrogen levels and a simple purification process. Various approaches, such as the generation of leaky mutants via chromosomal engineering,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b1fe51f7b4f4308bba59a582ee4261
https://doi.org/10.1021/acssynbio.7b00400
https://doi.org/10.1021/acssynbio.7b00400
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 43:97-102
Translational efficiency in Escherichia coli is strongly influenced by mRNA secondary structure of translational initiation region (TIR). We have previously reported that the expression of heterologous protein is directly related to the minimal foldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c14fa3a98f7454f1ae46f1179e8017
https://doi.org/10.1007/s10295-015-1699-1
https://doi.org/10.1007/s10295-015-1699-1
Publikováno v:
Biochimie. 151
We have previously constructed a novel polypeptide, PsTag, that should be useful in the development of biologics with properties comparable to those achievable by PEGylation, but with potentially less side effects. However, the low fermentation yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01d91982ae57300a62a2133736f35d7
https://pubmed.ncbi.nlm.nih.gov/29870802
https://pubmed.ncbi.nlm.nih.gov/29870802
Publikováno v:
British journal of pharmacology. 175(16)
BACKGROUND AND PURPOSE: Non‐alcoholic steatohepatitis (NASH) is the most severe form of non‐alcoholic fatty liver disease and is a serious public health problem around the world. There are currently no approved treatments for NASH. FGF21 has rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf6177d5fa1feb75cdd22f84a714b798
https://pubmed.ncbi.nlm.nih.gov/29859019
https://pubmed.ncbi.nlm.nih.gov/29859019
Publikováno v:
British journal of pharmacology. 173(14)
Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half-life (t1/2 ) to a clinically useful range. We developed a novel uncharged and unstructured recombinant polypeptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::678f7eddf7d4ab10558a24c807b2a4c3
https://pubmed.ncbi.nlm.nih.gov/27339749
https://pubmed.ncbi.nlm.nih.gov/27339749