Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lichen Bao"'
Publikováno v:
Molecules, Vol 28, Iss 3, p 1337 (2023)
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquitin-like modi
Externí odkaz:
https://doaj.org/article/1098785243254311b20f8874db040baf
Publikováno v:
Acta Biomaterialia. 164:74-93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d8c6b1e3c2d7bb1999e0584874e6bd
https://doi.org/10.1016/j.actbio.2023.04.019
https://doi.org/10.1016/j.actbio.2023.04.019
Publikováno v:
Journal of Controlled Release. 346:250-259
Multidrug resistance (MDR) to chemotherapeutic drugs and targeted drug delivery are recurring issues in clinical cancer treatment. Here, a multifunctional fusion protein-DNA conjugate was designed as a co-delivery vehicle for anticancer peptides and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b117833f5e515450533f31d2986affb
https://doi.org/10.1016/j.jconrel.2022.04.022
https://doi.org/10.1016/j.jconrel.2022.04.022
Autor:
Dingkang Liu, Chen Ye, Qun Wang, Jun Yin, Shan Hou, Lichen Bao, Xiangdong Gao, Wenbing Yao, Yali Yue
Publikováno v:
Cancer Letters. 452:38-50
The great therapeutic potential of peptides has not yet been achieved, mainly due to their remarkably short in vivo half-life. Although conjugation to macromolecules has been an effective way of improving protein in vivo half-life, the steric hindran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ace9c993d11afac85b593b6d2e8b05
https://doi.org/10.1016/j.canlet.2019.03.016
https://doi.org/10.1016/j.canlet.2019.03.016
Publikováno v:
Bioconjugate Chemistry. 30:898-906
Successful and efficient delivery of Cas9 protein and gRNA into cells is critical for genome editing and its therapeutic application. In this study, we developed an improved supercharged polypeptide (SCP) mediated delivery system based on dithiocyclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c4cc71dc0b1653ea9b27b1ab077dba
https://doi.org/10.1021/acs.bioconjchem.9b00022
https://doi.org/10.1021/acs.bioconjchem.9b00022
Publikováno v:
British Journal of Pharmacology. 175:3379-3393
Background and purpose Non-alcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world. There are currently no approved treatments for NASH. FGF21 has recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b07b1da756d865ac5289a055a96db5
https://doi.org/10.1111/bph.14383
https://doi.org/10.1111/bph.14383
Publikováno v:
ACS Synthetic Biology. 7:1291-1302
Escherichia coli extracellular expression systems have a number of advantages over other systems, such as lower pyrogen levels and a simple purification process. Various approaches, such as the generation of leaky mutants via chromosomal engineering,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b1fe51f7b4f4308bba59a582ee4261
https://doi.org/10.1021/acssynbio.7b00400
https://doi.org/10.1021/acssynbio.7b00400
Publikováno v:
British Journal of Pharmacology. 173:2208-2223
Background and purpose Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half-life (t1/2 ) to a clinically useful range. We developed a novel uncharged and unstructured r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::628c3afd0a59a1d8f53acf04e7b22d34
https://doi.org/10.1111/bph.13499
https://doi.org/10.1111/bph.13499
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 43:97-102
Translational efficiency in Escherichia coli is strongly influenced by mRNA secondary structure of translational initiation region (TIR). We have previously reported that the expression of heterologous protein is directly related to the minimal foldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c14fa3a98f7454f1ae46f1179e8017
https://doi.org/10.1007/s10295-015-1699-1
https://doi.org/10.1007/s10295-015-1699-1
Publikováno v:
Journal of the American Chemical Society. 140(49)
The efficient delivery of proteins into cells is needed to fully realize the potential of protein-based therapeutics. Current protein delivery strategies generally suffer from poor endosomal escape and low tolerance for serum. Here, the genetic fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bc57f15dfe2acfd172e8c852bbdaeb
https://pubmed.ncbi.nlm.nih.gov/30398334
https://pubmed.ncbi.nlm.nih.gov/30398334