Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lichchavi D. Rajasinghe"'
Autor:
Lauren K. Heine, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Quan-Zhen Li, Alexa L. Richardson, Ashleigh N. Tindle, Jenan J. Shareef, Jack R. Harkema, James J. Pestka
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Lupus, a systemic autoimmune disease shaped by gene-environment interplay, often progresses to endstage renal failure. While subchronic systemic exposure to bacterial lipopolysaccharide (LPS) triggers autoimmunity and glomerulonephritis in lupus-pron
Externí odkaz:
https://doaj.org/article/24dd03243e4e46369e01de89b45b93c9
Autor:
Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWorkplace exposure to respirable crystalline silica (cSiO2) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO2 instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-re
Externí odkaz:
https://doaj.org/article/1e54e2a2b11e4dc2b1e9f441abbd8a28
Autor:
Olivia K. Favor, Lichchavi D. Rajasinghe, Kathryn A. Wierenga, Krishna R. Maddipati, Kin Sing Stephen Lee, Andrew J. Olive, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPhagocytosis of inhaled crystalline silica (cSiO2) particles by tissue-resident alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA)
Externí odkaz:
https://doaj.org/article/c5241d8c3bfb4c839104b3a15452ac10
Autor:
Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulate
Externí odkaz:
https://doaj.org/article/9d62c3f710e94b838f4b340305d3c650
Autor:
Lichchavi D. Rajasinghe, Quan-Zhen Li, Chengsong Zhu, Mei Yan, Preeti S. Chauhan, Kathryn A. Wierenga, Melissa A. Bates, Jack R. Harkema, Abby D. Benninghoff, James J. Pestka
Publikováno v:
Autoimmunity, Vol 53, Iss 7, Pp 415-433 (2020)
Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that t
Externí odkaz:
https://doaj.org/article/88c45cb13ba94771ace3f1fe7e918ae4
Autor:
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to
Externí odkaz:
https://doaj.org/article/1b39b5825b9f4754b52009ab265ddf9b
Autor:
James J. Pestka, Peyman Akbari, Kathryn A. Wierenga, Melissa A. Bates, Kristen. N. Gilley, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Preeti S. Chauhan, Adam L. Lock, Quan-Zhen Li, Jack R. Harkema
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Workplace exposure to respirable crystalline silica dust (cSiO2) has been etiologically linked to the development of lupus and other human autoimmune diseases. Lupus triggering can be recapitulated in female NZBWF1 mice by four weekly intranasal inst
Externí odkaz:
https://doaj.org/article/90c7bbdff77a4cfdaf46a31f0c11d679
Autor:
Lichchavi D. Rajasinghe, Preeti S. Chauhan, Kathryn A. Wierenga, Augustus O. Evered, Shamya N. Harris, Melissa A. Bates, Mikhail A. Gavrilin, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO2), a known trigger of human autoimmune disease, elicits sterile inflammation and alveolar macrophage death in the lung that, in turn, induces early autoimmune onset and accelerate
Externí odkaz:
https://doaj.org/article/9c26a1a9e0164d58ae9d392d53d2f12c
Autor:
Kathryn A. Wierenga, Rita S. Strakovsky, Abby D. Benninghoff, Lichchavi D. Rajasinghe, Adam L. Lock, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Lupus is a systemic autoimmune disease typified by uncontrolled inflammation, disruption of immune tolerance, and intermittent flaring – events triggerable by environmental factors. Preclinical and clinical studies reveal that consumption of the ma
Externí odkaz:
https://doaj.org/article/017f16990df246459ca40f252e6debe8
Autor:
Kathryn A. Wierenga, Josephine Wee, Kristen N. Gilley, Lichchavi D. Rajasinghe, Melissa A. Bates, Mikhail A. Gavrilin, Andrij Holian, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Occupational exposure to respirable crystalline silica (cSiO2) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO2 triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, d
Externí odkaz:
https://doaj.org/article/1943c79994934e2fac188c8732bd0b4b