Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits

Autor: Kollmer, Marius, Meinhardt, Katrin, Haupt, Christian, Liberta, Falk, Wulff, Melanie, Linder, Julia, Handl, Lisa, Heinrich, Liesa, Loos, Cornelia, Schmidt, Matthias, Syrovets, Tatiana, Simmet, Thomas, Westermark, Per, Westermark, Gunilla T., Horn, Uwe, Schmidt, Volker, Walther, Paul, Fändrich, Marcus

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2016 May . 113(20), 5604-5609.

Externí odkaz: https://www.jstor.org/stable/26469898

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Autor: Bansal, Akanksha, Schmidt, Matthias, Rennegarbe, Matthies, Haupt, Christian, Liberta, Falk, Stecher, Sabrina, Puscalau-Girtu, Ioana, Biedermann, Alexander, Fändrich, Marcus

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications

Systemic AA amyloidosis is a world-wide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from serum amyloid A (SAA) protein. Using cryo electron microscopy we here show that amyloid fibrils w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27123064faa5f6357ec31ce18cff98f

Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.

Autor: Annamalai, Karthikeyan¹, Liberta, Falk¹, Vielberg, Marie ‐ Theres², Close, William¹, Lilie, Hauke³, Gührs, Karl ‐ Heinz⁴, Schierhorn, Angelika⁵, Koehler, Rolf⁶, Schmidt, Andreas¹, Haupt, Christian¹, Hegenbart, Ute⁷, Schönland, Stefan⁷, Schmidt, Matthias¹, Groll, Michael², Fändrich, Marcus¹ marcus.faendrich@uni-ulm.de

Publikováno v: Angewandte Chemie. 6/19/2017, Vol. 129 Issue 26, p7618-7622. 5p.

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils.

Autor: Bansal A; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Schmidt M; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Rennegarbe M; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Haupt C; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Liberta F; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Stecher S; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Puscalau-Girtu I; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Biedermann A; Institute of Protein Biochemistry, Ulm University, Ulm, Germany., Fändrich M; Institute of Protein Biochemistry, Ulm University, Ulm, Germany. marcus.faendrich@uni-ulm.de.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 12; Vol. 12 (1), pp. 1013. Date of Electronic Publication: 2021 Feb 12.