Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Libero Italo Giannola"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1361 (2021)
The currently available antifungal therapy for oral candidiasis (OC) has various limitations restricting its clinical use, such as short retention time, suboptimal drug concentration and low patients compliance. These issues could be overcome using m
Externí odkaz:
https://doaj.org/article/cf5c1e2ffa9c4f55a3c4e5169eb00405
Autor:
Giuseppe Ferraro, Giuditta Gambino, Viviana De Caro, Pierangelo Sardo, Flavia Maria Sutera, Valerio Rizzo, Fabio Carletti, Libero Italo Giannola
Publikováno v:
Current Pharmaceutical Design. 24:1849-1858
Background: The research on the improvement of epilepsy therapy is constantly growing. Valproyl-LPhenylalanine (VPA-Phen) and N-valproyl-L-tryptophan (VPA-Tryp) were synthesized to increase the antiepileptic efficacy of valproic acid. Methods: VPA-Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abde69cd2f0d7ce5888a8356753e4a7b
https://doi.org/10.2174/1381612824666180409095530
https://doi.org/10.2174/1381612824666180409095530
Publikováno v:
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1361, p 1361 (2021)
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1361, p 1361 (2021)
The currently available antifungal therapy for oral candidiasis (OC) has various limita- tions restricting its clinical use, such as short retention time, suboptimal drug concentration and low patients compliance. These issues could be overcome using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f700ef6bba293f4717bba294ff01a
https://doi.org/10.3390/pharmaceutics13091361
https://doi.org/10.3390/pharmaceutics13091361
Autor:
Flavia Maria Sutera, Fulvio Plescia, Viviana De Caro, Carla Cannizzaro, Libero Italo Giannola, Gianluca Lavanco
Publikováno v:
Behavioural Brain Research. 310:109-118
The mesolimbic dopamine (DA) system plays a key role in drug reinforcement and is involved in the development of alcohol addiction. Manipulation of the DAergic system represents a promising strategy to control drug-seeking behavior. Previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8850c0583608ac98f000ca86edf95b92
https://doi.org/10.1016/j.bbr.2016.05.006
https://doi.org/10.1016/j.bbr.2016.05.006
Publikováno v:
Therapeutic delivery. 8(10)
In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e33191a810ab14ed94318b7b23792d
https://pubmed.ncbi.nlm.nih.gov/28944742
https://pubmed.ncbi.nlm.nih.gov/28944742
The drug development process strives to predict metabolic fate of a drug candidate, together with its uptake in major organs, whether they act as target, deposit or metabolism sites, to the aim of establish a relationship between the pharmacodynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8d6b09bd4e472de2bea7aa9afbf36b
http://hdl.handle.net/10447/243438
http://hdl.handle.net/10447/243438
Publikováno v:
Europe PubMed Central
A major challenge in the development of novel neuro-therapeutic agents is to effectively overcome the blood-brain barrier (BBB), which acts as a 'working dynamic barrier'. The core problem in the treatment of neurodegenerative diseases is failed deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11952557606f3febdf4a1ff92ac7f0b2
https://pubmed.ncbi.nlm.nih.gov/27367188
https://pubmed.ncbi.nlm.nih.gov/27367188
Publikováno v:
Current Pharmaceutical Design. 18:5405-5410
The aim of this study was to investigate the potential for systemic administration of Methimazole (MMI) through the buccal mucosa as an alternative route for drug delivery. Considering that the most important restriction in buccal drug delivery could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ed96eb70f23b39e9f3925dca0a5eeb
https://doi.org/10.2174/138161212803307563
https://doi.org/10.2174/138161212803307563
Autor:
Maria Gabriella Siragusa, Vito Marcianò, Domenico Compilato, Fabio Bucchieri, Giulia Giandalia, Antonella Marino Gammazza, Viviana De Caro, Libero Italo Giannola, Giovanni Zummo, Alessandro Pitruzzella, Donna E. Davies, Alberto Fucarino, Carlo Paderni, Stephen T. Holgate, Felicia Farina, Giuseppina Campisi
Publikováno v:
Current Pharmaceutical Design. 18:5411-5420
Since the activity of several conventional anticancer drugs is restricted by resistance mechanisms and dose-limiting side-effects, the design of formulations for local application on malignant lesions seems to be an efficient and promising drug deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e6e906249b1a51a245f551605b987
https://doi.org/10.2174/138161212803307536
https://doi.org/10.2174/138161212803307536
Autor:
Maria Gabriella Siragusa, Flavia Maria Sutera, Libero Italo Giannola, V. De Caro, Giulia Giandalia
Publikováno v:
International Journal of Pharmaceutics. 429:78-83
The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2714e2fabe558ebaed6e1d12f045c7
https://doi.org/10.1016/j.ijpharm.2012.03.022
https://doi.org/10.1016/j.ijpharm.2012.03.022