Výsledky vyhledávání - "Liberato Brum Junior"

Akademický článek

Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

Autor: José A. Crippa, Luiz C. Pereira Junior, Lívia C. Pereira, Patrícia M. Zimmermann, Liberato Brum Junior, Letícia M. Rechia, Isabella Dias, Jaime E. Hallak, Alline C. Campos, Francisco S. Guimarães, Regina H. Queiroz, Antonio W. Zuardi

Publikováno v: Brazilian Journal of Psychiatry (2021)

Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli

Externí odkaz: https://doaj.org/article/760c3c83c5a5424c9c8aaece0c632303

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ELABORATION OF GUIDELINE FOR MONITORING IN RELATIVE BIOAVAILABILITY / PHARMACEUTICAL BIOEQUIVALENCE STUDY BY THE SPONSOR

Autor: Paula Thais Gozzi, Fernanda Giacomini Bueno, Patrícia Moura da Rosa Zimmermann, Liberato Brum Junior

Publikováno v: Arquivos de Ciências da Saúde da UNIPAR. 26

For registration of generic and similar drugs, it is necessary to carry out pharmaceutical equivalence (PE) tests and pharmaceutical bioequivalence (PB). To carry out these tests, duly qualified research centers are contracted, which need to be monit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a754f488443158072c0f7fac99932b83
https://doi.org/10.25110/arqsaude.v26i3.2022.8400

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Oral Cannabidiol Does Not Convert to Δ8-THC or Δ9-THC in Humans: A Pharmacokinetic Study in Healthy Subjects

Autor: Volnei José Tondo Filho, Sandra Aparecido Bernardo, Maria Eugênia Costa Queiroz, Jaime Eduardo Cecílio Hallak, José Alexandre de Souza Crippa, Carmem Maria Donaduzzi, Antonio Waldo Zuardi, Liberato Brum Junior, Bruna Miyazawa, Letícia Mello Rechia, Patrícia Moura da Rosa Zimmermann, Wagner Alex Jann Favreto, Francisco Silveira Guimarães, Silvane Guzzi, Alline C. Campos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Introduction: Recent studies have suggested that cannabidiol (CBD) could interconvert into Delta-8- and Delta-9- tetrahydrocannabinol. Materials and Methods: Thus, we tested the plasma samples of 120 healthy human subjects (60 male and 60 female), 60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac04686b3ff17e1cc74af0a1cbb0197
https://doi.org/10.1089/can.2019.0024

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Akademický článek

Determination of etoricoxib in human plasma using automated on-line solid-phase extraction coupled with LC-APCI/MS/MS

Autor: Sérgio Luiz Dalmora, Liberato Brum Junior, Ricardo Machado Ferretto, Paulo Renato de Oliveira, Thiago Barth, Maximiliano da Silva Sangoi

Publikováno v: Química Nova, Vol 31, Iss 3, Pp 574-578 (2008)

A liquid chromatography-tandem mass spectrometry method with atmospheric pressure chemical ionization (LC-APCI/MS/MS) was validated for the determination of etoricoxib in human plasma using antipyrin as internal standard, followed by on-line solid-ph

Externí odkaz: https://doaj.org/article/26d2c084b6a4435e8f789b10590f6742

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Akademický článek

Evaluation of the changes on hemostatic parameters induced by valdecoxib in male Wistar rats Avaliação dos efeitos do valdecoxibe sobre os parâmetros hemostáticos de ratos Wistar

Autor: Marcio Fronza, Micheli Wrasse, Liberato Brum Junior, Maximiliano S. Sangoi, Sérgio L. Dalmora

Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 28, Iss 1, Pp 28-32 (2006)

The effects of the cyclooxygenase (COX)-2 selective inhibitor, valdecoxib, on blood coagulation parameters were evaluated, along with aspirin in male Wistar rats. Groups of animals were administered a daily oral dose of 10 mg/kg rat of valdecoxib, 10

Externí odkaz: https://doaj.org/article/cb920fdcad29418eae2e1fb523c3ef8d

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Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

Autor: Regina Helena Costa Queiroz, Liberato Brum Junior, Patrícia Moura da Rosa Zimmermann, Isabella K. R. Dias, José Alexandre de Souza Crippa, Jaime Eduardo Cecílio Hallak, Francisco Silveira Guimarães, Lívia C. Pereira, Letícia Mello Rechia, Antonio Waldo Zuardi, Alline C. Campos, Luiz C. Pereira Junior

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Psychiatry v.44 n.1 2022
Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
Brazilian Journal of Psychiatry, Volume: 44, Issue: 1, Pages: 15-20, Published: 28 MAY 2021
Brazilian Journal of Psychiatry (2021)
Brazilian Journal of Psychiatry, Issue: ahead, Published: 28 MAY 2021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8426b8ad9df5f76272fef23c83ae2875
https://pubmed.ncbi.nlm.nih.gov/34076067

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Biological bases for a possible effect of cannabidiol in Parkinson’s disease

Autor: Nilson C. Ferreira-Junior, Liberato Brum Junior, Jaime Eduardo Cecílio Hallak, Patrícia Moura da Rosa Zimmermann, José Alexandre de Souza Crippa, Francisco Silveira Guimarães, Alline C. Campos, Antonio Waldo Zuardi, Elaine Del-Bel

Publikováno v: Brazilian Journal of Psychiatry, Issue: ahead, Published: 15 JUL 2019
Brazilian Journal of Psychiatry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Psychiatry v.42 n.2 2020
Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Associação Brasileira de Psiquiatria (ABP)
instacron:ABP

Objective: Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients’ quality of life with fewer side effects are needed, but not yet availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7de69e7cc255470031f46c40a4a66b
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019005012104&lng=en&tlng=en

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DESAFIOS DO DESENVOLVIMENTO DOS DOSSIÊS DE REGISTRO DE MEDICAMENTOS FITOTERÁPICOS

Autor: Liberato Brum Junior, Josélia Larger Manfio

Publikováno v: Arquivos de Ciências da Saúde da UNIPAR. 21

Os benefícios da utilização de plantas medicinais são amplamente discutidos no âmbito acadêmico através de pesquisa básica e pela população em geral, baseado no ainda presente uso tradicional. Porém, é evidente a baixa demanda por registr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af86b1a698f1450ef4606c8814a41c11
https://doi.org/10.25110/arqsaude.v21i1.2017.5863

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DEVELOPMENT AND VALIDATION OF AN LC-MS/MS METHOD FOR THE PRE-CLINICAL PHARMACOKINETIC INVESTIGATION OF THE ANTICANCER CANDIDATE AC04 IN RODENTS

Autor: Ivan da Rocha Pitta, Maria do Carmo Alves de Lima, Liberato Brum Junior, Teresa Dalla Costa, Sandra Elisa Haas, Suely Lins Galdino, Flávia De Toni Uchôa, Maiara Cássia Pigatto

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 34:744-752

A liquid chromatography-tandem mass spectrometry method was developed for accurate quantification of the acridinic anticancer candidate AC04 (5-acridin-9-ylmethylene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) in rat plasma viewing the drug's pre-cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c1e4ed58f9c5fff22074d72e296125e
https://doi.org/10.1080/10826076.2011.563890

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