TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.

Autor: Bulger EA; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA 94158, USA., Muncie-Vasic I; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA and University of California, Berkeley, Berkeley, CA 94720, USA., Libby ARG; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA 94158, USA., McDevitt TC; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., Bruneau BG; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA.; Department of Pediatrics, University of California, San Francisco, CA 94158, USA.; Institute for Human Genetics, University of California, San Francisco, CA 94158, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158, USA.

Publikováno v: Development (Cambridge, England) [Development] 2024 Mar 15; Vol. 151 (6). Date of Electronic Publication: 2024 Mar 28.

Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.

Autor: Vasic I; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA., Libby ARG; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Ph.D. Program, University of California, San Francisco, San Francisco, CA 94158, USA., Maslan A; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Bulger EA; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Ph.D. Program, University of California, San Francisco, San Francisco, CA 94158, USA., Zalazar D; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Krakora Compagno MZ; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Streets A; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Tomoda K; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Center for iPS Cell Research and Application, Kyoto 606-8397, Japan., Yamanaka S; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Center for iPS Cell Research and Application, Kyoto 606-8397, Japan. Electronic address: shinya.yamanaka@gladstone.ucsf.edu., McDevitt TC; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: todd.mcdevitt@gladstone.ucsf.edu.

Publikováno v: Developmental cell [Dev Cell] 2023 Aug 21; Vol. 58 (16), pp. 1477-1488.e5. Date of Electronic Publication: 2023 Jun 23.

Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis.

Autor: Joy DA; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, San Francisco, CA, USA; Gladstone Institutes, San Francisco, CA, USA., Libby ARG; Gladstone Institutes, San Francisco, CA, USA; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, San Francisco, CA, USA., McDevitt TC; Gladstone Institutes, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: todd.mcdevitt@gladstone.ucsf.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2021 May 11; Vol. 16 (5), pp. 1317-1330.

Engineering the Spatiotemporal Mosaic Self-Patterning of Pluripotent Stem Cells.

Autor: Libby ARG; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA, USA.; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA., Joy DA; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, San Francisco, CA, USA., McDevitt TC; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA. todd.mcdevitt@gladstone.ucsf.edu.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. todd.mcdevitt@gladstone.ucsf.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2258, pp. 105-116.