CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Autor: Delconte RB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Kolesnik TB; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Shi W; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Putz EM; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Stannard K; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Zhang JG; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Teh C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Firth M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Ushiki T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Andoniou CE; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Degli-Esposti MA; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia and Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Sharp PP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Sanvitale CE; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Infusini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Liau NP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Linossi EM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Burns CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Carotta S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Gray DH; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Seillet C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Hutchinson DS; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Belz GT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Webb AI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Alexander WS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Li SS; Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada., Bullock AN; Structural Genomics Consortium (SGC), University of Oxford, Oxford, UK., Babon JJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Smyth MJ; Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; School of Medicine, University of Queensland, Herston, Queensland, Australia., Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Victoria, Australia.

Publikováno v: Nature immunology [Nat Immunol] 2016 Jul; Vol. 17 (7), pp. 816-24. Date of Electronic Publication: 2016 May 23.

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Autor: Varghese LN, Ungureanu D; ‡School of Medicine, University of Tampere and Tampere University Hospital, Tampere 33014, Finland., Liau NP, Young SN; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia., Laktyushin A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia., Hammaren H; ‡School of Medicine, University of Tampere and Tampere University Hospital, Tampere 33014, Finland., Lucet IS; §Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia., Nicola NA, Silvennoinen O; ‡School of Medicine, University of Tampere and Tampere University Hospital, Tampere 33014, Finland., Babon JJ, Murphy JM

Publikováno v: The Biochemical journal [Biochem J] 2014 Mar 01; Vol. 458 (2), pp. 395-405.