Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger

Autor: Moshe Giladi, Reuben Hiller, Liat van Dijk, Mary Hongying Cheng, Daniel Khananshvili, Bosmat Refaeli, Ivet Bahar

Publikováno v: Cell Calcium. 76:10-22

Prokaryotic and eukaryotic Na(+)/Ca(2+) exchangers (NCX) control Ca(2+) homeostasis. NCX orthologs exhibit up to 10(4)-fold differences in their turnover rates (k(cat)), whereas the ratios between the cytosolic (cyt) and extracellular (ext) K(m) valu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485b2f48084a0273f72a918e296a3552
https://doi.org/10.1016/j.ceca.2018.09.004

Dynamic distinctions in the Na + /Ca 2+ exchanger adopting the inward- and outward-facing conformational states

Autor: Bosmat Refaeli, Petr Man, Liat van Dijk, Moshe Giladi, Eric Forest, Daniel Khananshvili, Lior Almagor, Reuben Hiller

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (29), pp.12311-12323. ⟨10.1074/jbc.M117.787168⟩
Journal of Biological Chemistry, 2017, 292 (29), pp.12311-12323. ⟨10.1074/jbc.M117.787168⟩

International audience; Na(+)/Ca(2+) exchanger (NCX) proteins operate through the alternating access mechanism, where the ion-binding pocket is exposed in succession either to the extracellular or the intracellular face of the membrane. The archaeal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db149f8e673c6fd57bdf26a6166aeece
https://hal.archives-ouvertes.fr/hal-01647025

Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium–calcium exchanger (NCX_Mj)

Autor: Liat van Dijk, Reuben Hiller, Moshe Giladi, Tal Buki, Daniel Khananshvili, Lior Almagor

Publikováno v: Cell Calcium. 56:276-284

Dynamic features of Ca(2+) interactions with transport and regulatory sites control the Ca(2+)-fluxes in mammalian Na(+)/Ca(2+)(NCX) exchangers bearing the Ca(2+)-binding regulatory domains on the cytosolic 5L6 loop. The crystal structure of Methanoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9831aa4226d0f384b22539acc91df1f7
https://doi.org/10.1016/j.ceca.2014.08.010