Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Liarozole"'
Akademický článek
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Autor:
Valérie De Glas, Benoît Balau, Haoming Liu, Yves Poumay, J. Veit, Philippe Diaz, Florence Bourlond, Amy S. Paller
Publikováno v:
Veit, J, DE GLAS, VALERIE, Balau, B, Liu, H, Bourlond, F, Paller, A, Poumay, Y & Diaz, P 2021, ' Characterization of CYP26B1-selective inhibitor, DX314, as a potential therapeutic for keratinization disorders ', The journal of investigative dermatology, vol. 141, pp. 72-83 . https://doi.org/10.1016/j.jid.2020.05.090
J Invest Dermatol
J Invest Dermatol
Inhibition of CYP450-mediated retinoic acid (RA) metabolism by RA metabolism blocking agents increases endogenous retinoids and is an alternative to retinoid therapy. Currently available RA metabolism blocking agents (i.e., liarozole and talarozole)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1f3fff9a59c77d834b3586b555612a
https://pure.unamur.be/ws/files/43540083/JID_2020_0105.R2_Proof_hi.pdf
https://pure.unamur.be/ws/files/43540083/JID_2020_0105.R2_Proof_hi.pdf
Akademický článek
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Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:246-258
All-trans retinoic acid (atRA) is a front-line treatment of acute promyelocytic leukemia (APL). Due to its activity in regulating the cell cycle, it has also been evaluated for the treatment of other cancers. However, the efficacy of atRA has been li
PURPOSEXenopushas the remarkable ability to regenerate a lens from the basal cornea epithelial cells in response to signals from the retina. Previous work demonstrated that the Retinoic Acid (RA) metabolizing enzyme CYP26 is expressed in the cornea,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a5bf9b79388d56f21b80368a405253
Akademický článek
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Publikováno v:
The British Journal of Dermatology
British Journal of Dermatology, 170(1), 173-181. Wiley
British Journal of Dermatology, 170(1), 173-181. Wiley
Oral liarozole, a retinoic acid metabolism-blocking agent, may be an alternative to systemic retinoid therapy in patients with lamellar ichthyosis.To demonstrate the efficacy and safety of once-daily oral liarozole in the treatment of moderate/severe
Autor:
Dorette Freyer, Golo Kronenberg, Karen Gertz, Matthias Endres, Ria Uhlemann, Julian Hellmann-Regen
Publikováno v:
Journal of Neuroimmunology. 256:1-6
In the brain, retinoic acid (RA) concentrations are under tight spatio-temporal control. Here, we show that challenge of primary mouse microglia with lipopolysaccharide (LPS) results in increased release of nitric oxide (NO) and tumor necrosis factor
Publikováno v:
Fertility and Sterility. 98:1557-1562
Objective To study the influence of liarozole on leiomyoma cell proliferation and extracellular matrix (ECM) gene expression in immortalized leiomyoma cells. Design Laboratory study. Setting University hospital. Patient(s) None. Intervention(s) Tissu
Publikováno v:
Molecules
Molecules; Volume 21; Issue 3; Pages: 351
Molecules, Vol 21, Iss 3, p 351 (2016)
Molecules; Volume 21; Issue 3; Pages: 351
Molecules, Vol 21, Iss 3, p 351 (2016)
A new CYP26A1 homology model was built based on the crystal structure of cyanobacterial CYP120A1. The model quality was examined for stereochemical accuracy, folding reliability, and absolute quality using a variety of different bioinformatics tools.