Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Liaqat Masih"'
Autor:
Jun-Ho Maeng, Kevin G. Pattamana, Yeyu Cao, Zhicai Yang, Bruce F. Molino, Liaqat Masih, Frederic Bois, David D. Manning
Publikováno v:
Synthesis. 44:63-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad72eee50e0a61acf9ea6e7ec9c2c61
https://doi.org/10.1055/s-0031-1289616
https://doi.org/10.1055/s-0031-1289616
Autor:
Timothy Rust, Carla Hassler, James P. Harding, Justin J. Richards, Brian I. Bliss, Yuri L. Khmelnitsky, David D. Manning, Marlene L. Cohen, Liaqat Masih, Michael A. Lynch, Jianqing Chen, Kevin L. Christensen, Zhicai Yang, Soshanna Isaacson, Jonathan D. Wierschke, Cathy M. Beer, Russell J. DeOrazio, Jun-Ho Maeng, Lisa H. Peterson, Christopher L. Cioffi, Alexander Usyatinsky, Kevin Fitzpatrick, David J. Fairfax, Matthew Isherwood, Svetlana Dobritsa, W. Martin Rennells
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6538-6541
A new class of 2-substituted benzoxazole carboxamides are presented as potent functional 5-HT(3) receptor antagonists. The chemical series possesses nanomolar in vitro activity against human 5-HT(3)A receptors. A chemistry optimization program was co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f332105939c77bf627dc617b2e13b623
https://doi.org/10.1016/j.bmcl.2010.09.038
https://doi.org/10.1016/j.bmcl.2010.09.038
Autor:
Cheng Guo, Liaqat Masih, David D. Manning, Peter R. Guzzo, Kristen N. Ryan, Jonathan D. Wierschke, Sok Hui Choo, William G. Earley, Nicholas M. Barnes, Zhenjun Zhang, Jennifer Naginskaya, Amy S Newman, Catherine A. Brady
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(11)
Serotonin type 3 (5-HT3) receptor partial agonists have been targeted as potential new drugs for the symptomatic relief of irritable bowel syndrome (IBS). Multiple diazepinone-based compounds have been discovered, which exhibit nanomolar binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c335733d1983989f1f5c9d6a38536306
https://pubmed.ncbi.nlm.nih.gov/24755431
https://pubmed.ncbi.nlm.nih.gov/24755431
Autor:
Amy S. Butler, Catherine A. Brady, Svetlana Dobritsa, Marlene L. Cohen, Carla Hassler, Sok Hui Choo, Kristen N. Ryan, Nicholas M. Barnes, Alexander Usyatinsky, M. Inthikhab Sikkander, Christopher L. Cioffi, Kevin Fitzpatrick, Liaqat Masih, Zhenjun Zhang, David D. Manning, Jonathan D. Wierschke, Peter R. Guzzo, William G. Earley, Cheng Guo, Jennifer Naginskaya
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Serotonin type 3 (5-HT(3)) receptor partial agonists are being targeted as potential new drugs for the treatment of irritable bowel syndrome (IBS). Two new chemical series bearing indazole and indole cores have exhibited nanomolar binding affinity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bbdebdbe2f35d1a58c32fffc956826
https://pubmed.ncbi.nlm.nih.gov/21146988
https://pubmed.ncbi.nlm.nih.gov/21146988
Autor:
William F. Vernier, David R. Anderson, Shridhar Hegde, Aruna Sambandam, Shuang Liu, Leslie Gomez, Liaqat Masih, Emily J. Reinhard, Len F. Lee, Patricia A. Snider
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(6)
A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFalpha in U93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839b2c5bc4955012d6d36592a9365c29
https://pubmed.ncbi.nlm.nih.gov/15745802
https://pubmed.ncbi.nlm.nih.gov/15745802