Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Lianyu Shan"'
Autor:
Lianyu Shan, Mojdeh Matloubi, Ifeoma Okwor, Sam Kung, Mohamed Sadek Almiski, Sujata Basu, Andrew Halayko, Latifa Koussih, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309868 (2024)
Dendritic cells (DCs) are pivotal in regulating allergic asthma. Our research has shown that the absence of Sema3E worsens asthma symptoms in acute and chronic asthma models. However, the specific role of PlexinD1 in these processes, particularly in
Externí odkaz:
https://doaj.org/article/2f0cab41bf624d9d9c70bd1042d48553
Publikováno v:
Advances in Biomedical and Health Sciences, Vol 1, Iss 4, Pp 189-195 (2022)
Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine
Externí odkaz:
https://doaj.org/article/3b6710ae54794371b2722977fb328743
Autor:
Jyoti Balhara, Latifa Koussih, Ashfaque Mohammed, Lianyu Shan, Bouchaib Lamkhioued, Abdelilah S. Gounni
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
PTX3 is a unique member of the long pentraxins family and plays an indispensable role in regulating the immune system. We previously showed that PTX3 deletion aggravates allergic inflammation via a Th17 -dominant phenotype and enhanced CD4 T cell sur
Externí odkaz:
https://doaj.org/article/6acdcf4150b04c8c8d649b0c937c4981
Autor:
Hesam Movassagh, Lianyu Shan, Latifa Koussih, Abdulaziz Alamri, Nazila Ariaee, Sam K P Kung, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252868 (2021)
Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The precise mechanisms underlying dendritic cell functions have remained to be addressed. Semaphorin
Externí odkaz:
https://doaj.org/article/3d4a970dab344957a40f014fb329ce8e
Autor:
Gaurav Gupta, Zhirong Mou, Ping Jia, Rohit Sharma, Romaniya Zayats, Sayonara M. Viana, Lianyu Shan, Aldina Barral, Viviane S. Boaventura, Thomas T. Murooka, Abdel Soussi-Gounni, Camila I. de Oliveira, Jude E. Uzonna
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108513- (2020)
Summary: The long pentraxin 3 (PTX3) plays a critical role in inflammation, tissue repair, and wound healing. Here, we show that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression increases in skin lesions in patient
Externí odkaz:
https://doaj.org/article/aaefd71d64124fd1a867b9f493e7fb4a
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220772 (2019)
Pentraxin-3 (PTX3) is a multifunctional protein involved in both innate and adaptive immunity. Glucocorticoid (GC) is the first-line therapy to mitigate airway inflammation in asthma. Previous pieces of evidence showed that GC has divergent effects o
Externí odkaz:
https://doaj.org/article/a085ce45733645ce9d4877c1be11f5e4
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93946 (2014)
Previous studies have shown that enhanced accumulation of contractile proteins such as smooth muscle myosin light chain kinase (smMLCK) plays a major role in human airway smooth muscle cells (HASM) cell hypercontractility and hypertrophy. Furthermore
Externí odkaz:
https://doaj.org/article/e1c77ab51d19426388a3ed688468451c
Autor:
Jingbo Zhang, Lianyu Shan, Latifa Koussih, Naresh Singh Redhu, Andrew J Halayko, Jamila Chakir, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34965 (2012)
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 is produced by immune and structural cells. However, very little is known about the expression of PTX3 and its role in
Externí odkaz:
https://doaj.org/article/0916f02e21264c5caa94638feece4675
Autor:
Naresh Singh Redhu, Ali Saleh, Lianyu Shan, William T Gerthoffer, Sam K Kung, Andrew J Halayko, Bouchaib Lamkhioued, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6153 (2009)
BACKGROUND:The high affinity IgE receptor (FcepsilonRI) is a crucial structure for IgE-mediated allergic reactions. We have previously demonstrated that human airway smooth muscle (ASM) cells express the tetrameric (alphabetagamma2) FcepsilonRI, and
Externí odkaz:
https://doaj.org/article/febe1ff7ccd742c3a3f4595c86f6a9ca
Autor:
Martin P Alphonse, Arash S Saffar, Lianyu Shan, Kent T HayGlass, F Estelle R Simons, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1921 (2008)
The high affinity IgE receptor, Fc epsilonRI, plays a key role in the immunological pathways involved in allergic asthma. Previously we have demonstrated that human neutrophils isolated from allergic asthmatics express a functional Fc epsilonRI, and
Externí odkaz:
https://doaj.org/article/aa0c14493d7b4c9d98eedfa6a289ab0b