Gynura segetum induces hepatic sinusoidal obstruction syndrome in mice by impairing autophagy

Autor: Hui Zhang, Shu Jia, Lianyu Jin, Jianzuo Yao MB, Zhihong Shen, Jingyi Wu, Xiaokun Yao, Danwei Chen, Congcong Zhang, Shufang Yu, Ningwei Zhu, Lexiao Jin, Xiaomin Yao

Publikováno v: Acta Cirúrgica Brasileira, Vol 36, Iss 11 (2022)

ABSTRACT Purpose: To investigate the underlying mechanism of hepatic sinusoidal obstruction syndrome (HSOS) induced by Gynura segetum by measuring autophagy in mouse models. Methods: The model group was administered G. segetum (30 g/kg/d) by gavage,

Externí odkaz: https://doaj.org/article/be91eaf3599c4cb498f850b91f5e1508

Bicyclol alleviates high-fat diet-induced hepatic ER stress- and autophagy-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in mice

Autor: Shu, Jia, Lianyu, Jin, Xiaoyan, Cheng, Jingyi, Wu, Xiaokun, Yao, Jingping, Shao, Congcong, Zhang, Danwei, Cen, Bin, Cheng, Jing, Wang, Lei, Chen, Xiaomin, Yao

Publikováno v: Drug Development and Industrial Pharmacy. 48:247-254

Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver, and non-alcoholic steatohepatitis (NASH) represents its advanced stage. Bicyclol has protective activity against NAFLD in mice; however, the effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27b2c5fe18056c77690c6d29bd33788
https://doi.org/10.1080/03639045.2022.2106238

Gynura segetum induces hepatic sinusoidal obstruction syndrome in mice by impairing autophagy

Autor: Hui Zhang, Shu Jia, Lianyu Jin, Jianzuo Yao MB, Zhihong Shen, Jingyi Wu, Xiaokun Yao, Danwei Chen, Congcong Zhang, Shufang Yu, Ningwei Zhu, Lexiao Jin, Xiaomin Yao

Publikováno v: Acta Cirúrgica Brasileira, Volume: 36, Issue: 11, Article number: e361104, Published: 18 FEB 2022
Acta Cirúrgica Brasileira v.36 n.11 2021
Acta Cirúrgica Brasileira
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC

Purpose: To investigate the underlying mechanism of hepatic sinusoidal obstruction syndrome (HSOS) induced by Gynura segetum by measuring autophagy in mouse models. Methods: The model group was administered G. segetum (30 g/kg/d) by gavage, while the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f237cf58412d7d84787037025cfad3
https://doi.org/10.1590/acb361104