Leveraging Stereoelectronic Effects in Biofilm Eradication: Synthetic β-Amino Human Milk Oligosaccharides Impede Microbial Adhesion As Observed by Scanning Electron Microscopy

Autor: Kelly M. Craft, Steven D. Townsend, Schuyler A. Chambers, Lianyan L Xu, Johny M. Nguyen, Keevan C. Marion, Jennifer A. Gaddy, Rebecca E. Moore

Publikováno v: J Org Chem

Alongside Edward, Lemieux was among the earliest researchers studying negative hyperconjugation (i.e. the anomeric effect) or the preference for gauche conformations about the C1-O5 bond in carbohydrates. Lemieux also studied an esoteric, if not cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6796471fbb7a39c5e74722a9e47ee16
https://doi.org/10.1021/acs.joc.0c01958

An effective reagent to functionalize alcohols with phosphocholine

Autor: Steven D. Townsend, D. Jamin Keith, Lawrence J. Berg, Lianyan L Xu

Publikováno v: Org Biomol Chem

Phosphocholine is a small haptenic molecule that is both a precursor and degradation product of choline. Phosphocholine decorates a number of biologics such as lipids and oligosaccharides. In this study, an air and bench stable phosphocholine donor h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275f763ef2d6f21e47385c525a31284b
https://pubmed.ncbi.nlm.nih.gov/31912847

Microwave-Assisted, Asymmetric Synthesis of 3-Amino-2,3-Dihydrobenzofuran Flavonoid Derivatives from Chalcones

Autor: Yash R. Mehta, Lianyan L. Xu, Leslie N. Aldrich, Travis R. Helgren, Ivan Pavlinov, Melissa A. Korkmaz, Daniel Sotelo

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(18)

A route to access 3-amino-2,3-dihydrobenzofurans that utilizes microwave-assisted organic synthesis to rapidly generate analogues has been developed. The route begins with an acid-catalyzed, microwave-assisted aldol condensation to generate chalcone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbce242e2afc32cdd1abd2a9447cdb8
https://pubmed.ncbi.nlm.nih.gov/29446184

ECM2 and GLT8D2 in human pulmonary artery hypertension: fruits from weighted gene co-expression network analysis.

Autor: Bai Z; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Lab of Molecular Biological Targeted Therapies of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Xu L; Department of Radiology, Peking Union Medical College Hospital, PUMC & CAMS, Beijing, China., Dai Y; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Lab of Molecular Biological Targeted Therapies of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yuan Q; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Lab of Molecular Biological Targeted Therapies of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhou Z; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Lab of Molecular Biological Targeted Therapies of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Publikováno v: Journal of thoracic disease [J Thorac Dis] 2021 Apr; Vol. 13 (4), pp. 2242-2254.