Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lianxiang Bi"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 558-572 (2023)
Coronary artery venous bypass grafts typically fail because of atherosclerosis driven by lipid and macrophage accumulation. Therapy for vein-graft atherosclerosis is limited to statin drugs, which are only modestly effective. We hypothesized that tra
Externí odkaz:
https://doaj.org/article/0bb220201f12424e87cc8fd11799d3dc
Autor:
Meena Sethuraman, Nagadhara Dronadula, Lianxiang Bi, Bradley K. Wacker, Ethan Knight, Pieter De Bleser, David A. Dichek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Transduction of endothelial cells (EC) with a vector that expresses apolipoprotein A-I (APOAI) reduces atherosclerosis in arteries of fat-fed rabbits. However, the effects on atherosclerosis are partial and might be enhanced if APOAI express
Externí odkaz:
https://doaj.org/article/2ad6ece108b24aa594c3f46484bd534d
Autor:
Lianxiang Bi, Bradley K. Wacker, Emma Bueren, Ervin Ham, Nagadhara Dronadula, David A. Dichek
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 96-111 (2017)
Coronary artery bypass vein grafts are a mainstay of therapy for human atherosclerosis. Unfortunately, the long-term patency of vein grafts is limited by accelerated atherosclerosis. Gene therapy, directed at the vein graft wall, is a promising appro
Externí odkaz:
https://doaj.org/article/08277880b0d9448b9216520e24c2ffaa
Autor:
Chloe Y. Lee, Stoyan N. Angelov, Jay Zhu, Lianxiang Bi, Nicole Sanford, Ilkay Alp Yildirim, David A. Dichek
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:764-771
Background: To test the hypothesis that smooth muscle cell (SMC) TGF-β (transforming growth factor beta) signaling contributes to maintenance of aortic structure and function beyond the early postnatal period. Methods: We deleted the TBR2 (type 2 TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d414c83bd0bfbd48173cb2639c7a216f
https://doi.org/10.1161/atvbaha.122.317603
https://doi.org/10.1161/atvbaha.122.317603
Autor:
Bradley K. Wacker, Lianxiang Bi, Li Liu, Mary G. Sorci-Thomas, Philip Ng, Donna J. Palmer, Chongren Tang, David A. Dichek
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1868:159301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11684eb329b1272e0c80ce9f06b95ad8
https://doi.org/10.1016/j.bbalip.2023.159301
https://doi.org/10.1016/j.bbalip.2023.159301
Autor:
Lianxiang Bi, David A. Dichek, Alexis Stamatikos, Meena Sethuraman, Bradley K. Wacker, Kaushik Komandur
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Efficient gene transfer to the vascular wall via intravenous vector injection would be useful for experimental vascular biology and gene therapy. Initial studies of lentiviral vec
Objective: Efficient gene transfer to the vascular wall via intravenous vector injection would be useful for experimental vascular biology and gene therapy. Initial studies of lentiviral vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e7cb8767573b26c8482d7c2d942bb8
https://doi.org/10.1161/atvbaha.120.315125
https://doi.org/10.1161/atvbaha.120.315125
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Introduction: Coronary artery venous bypass grafts typically fail because of accelerated atherosclerosis, driven by lipid infiltration and by accumulation of macrophages and other cells. We previously showed that transduction of carotid artery endoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d881ab2d807071559bfe64e7e81d0c65
https://doi.org/10.1161/atvb.42.suppl_1.444
https://doi.org/10.1161/atvb.42.suppl_1.444
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background: Obstructed arteries are often treated by surgical implantation of venous bypass grafts. Vein grafts can fail for many reasons, including thrombosis, atherosclerosis, or anastomotic stenoses (narrowings where the grafts connect to the arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3cc951a7b5d09cd364ce5e9c2e4b638
https://doi.org/10.1161/atvb.42.suppl_1.482
https://doi.org/10.1161/atvb.42.suppl_1.482
Autor:
Bradley K Wacker, Lianxiang Bi, Mary Sorci-Thomas, Philip Ng, Donna Palmer, Chongren Tang, David Dichek
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Introduction: Gene therapy using a helper-dependent adenovirus (HDAd) to express rabbit apolipoprotein (apo) AI in carotids of fat-fed rabbits reduces atherosclerosis. We hypothesize that transgenic apoAI promotes reverse cholesterol transport from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5686ec042b8a2a9bbddef14c5f14450f
https://doi.org/10.1161/atvb.42.suppl_1.430
https://doi.org/10.1161/atvb.42.suppl_1.430
Autor:
Lianxiang Bi, Bradley K. Wacker, Ethan Knight, Chongren Tang, Lucia Vojtech, Alexis Stamatikos, David A. Dichek
Publikováno v:
Hum Gene Ther
Atherosclerosis is a disease of large- and medium-sized arteries that is caused by cholesterol accumulation in arterial intimal cells, including macrophages and smooth muscle cells (SMC). Cholesterol accumulation in these cells can be prevented or re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241e90de6bc7a16170694d374b35d8cc
https://doi.org/10.1089/hum.2019.245
https://doi.org/10.1089/hum.2019.245