Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Liansuo Zu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Stereoisomeric polycyclic natural products are important for drug discovery-based screening campaigns, due to the close correlation of stereochemistry with diversified bioactivities. Nature generates the stereoisomeric yohimbine alkaloids us
Externí odkaz:
https://doaj.org/article/8601796e067d4aaf85d4f60aa8d32a6a
Autor:
Yanfeng Wang, Shaopeng Chi, Huifang Guo, Guang Li, Li Wang, Qiancheng Zhao, Yu Rao, Liansuo Zu, Wei He, Bailong Xiao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.
Externí odkaz:
https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c
Publikováno v:
Chemical Science; 8/28/2024, Vol. 15 Issue 32, p12732-12738, 7p
Publikováno v:
Chinese Chemical Letters. 33:2433-2436
The first total synthesis of dracaenins A and B is achieved in four steps. The synthesis features the convergent coupling of three readily available fragments with minimized use of protecting groups. The chemical synthesis enables the discovery of th
The migration selectivity of Cb-substituted-4aH-carbazoles has been studied by DFT methods. For n-Bu and Ph substituted sub-strates, C4 migration and Ca-C1 migration are all pericyclic. C4 migration is favorable for more aromatic transition states. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae09d2ae0a02cc4a830703e813872595
https://doi.org/10.26434/chemrxiv-2023-4m5mk
https://doi.org/10.26434/chemrxiv-2023-4m5mk
Publikováno v:
Organic Chemistry Frontiers. 9:5383-5394
The synthetic utility of rearrangement reactions in total synthesis for the rapid construction of core skeletons, the precise control of stereochemistry, and the identification of suitable synthons has been discussed.
Publikováno v:
Angewandte Chemie International Edition. 61
A direct spirocyclization approach for the chemical synthesis of spiro[cyclohexane-2-indoline] alkaloids is reported. The absolute stereochemistry was introduced by a desymmetrizing Dieckmann condensation, and the relative stereochemistry was control
Publikováno v:
Organic letters. 24(40)
From methyl jasmonate, the concise asymmetric total synthesis of uleine alkaloid gilbertine was reported. The synthesis demonstrated the power of a cyclopentanone-based approach involving the coupling of 2-aminobenzaldehyde and diazo-cyclopentanone f
Autor:
Zhi Zhang, Liansuo Zu
Publikováno v:
Organic Letters. 23:2222-2226
Asperversin A represents the first example of a steroid-sterigmatocystin heterodimer. We report the concise asymmetric total synthesis of this natural product in 11 steps (the longest linear sequence). The polycyclic ring system was constructed by a
Publikováno v:
Organic Chemistry Frontiers. 8:5668-5673
We report a mild method for the synthesis of 4aH-carbazole intermediates with significant synthetic flexibility and variability, and demonstrate the controllable rearrangements of such intermediates to carbazoles. The work further enriches the chemis