Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lianne E. Rotin"'
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTIntroduction Allogeneic hematopoietic stem cell transplant (HSCT) and gene therapy (GT) are two potentially curative approaches for sickle cell disease (SCD), but they have never been compared in clinical trials.Objective To compare the safet
Externí odkaz:
https://doaj.org/article/2e71f756e0e3469f80668452eac7521a
Autor:
Lianne E. Rotin, Neil MacLean, Ahmed Aman, Marcela Gronda, Feng-Hsu Lin, Rose Hurren, XiaoMing Wang, Jeffrey L Wrana, Alessandro Datti, Rima Al-awar, Mark D. Minden, Aaron D. Schimmer
Publikováno v:
Haematologica, Vol 101, Iss 11 (2016)
Externí odkaz:
https://doaj.org/article/5cfc0304e17b4b0d81b8ba9f953e109a
Publikováno v:
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
Publikováno v:
CMAJ : Canadian Medical Association Journal
Publikováno v:
CMAJ : Canadian Medical Association Journal
KEY POINTS A 30-year-old man presented to our emergency department with left-sided chest pain. His medical history included irritable bowel syndrome, recurrent sinusitis and persistent symptoms of dry mouth, which started after a remote tonsillectomy
Publikováno v:
Blood. 136:11-12
Background: Patients with sickle cell disease (SCD) have reduced life expectancy and high morbidity, despite treatments such as hydroxyurea, transfusion, vaccination, and antibiotic prophylaxis. Both allogeneic hematopoietic stem cell transplant (HSC
Autor:
Lianne E Rotin, Rose Hurren, Mark D. Minden, Xiaoming Wang, Marcela Gronda, Malik Slassi, Aaron D. Schimmer
Publikováno v:
Leukemia & Lymphoma. 57:2432-2436
Bruton’s tyrosine kinase (BTK) is a potential therapeutic target in acute myeloid leukemia (AML) and the small molecule BTK inhibitor ibrutinib has been found to potentiate the cytotoxic activity o...
Autor:
Rose Hurren, Marcela Gronda, Neil MacLean, Feng-Hsu Lin, Alessandro Datti, Lianne E Rotin, Xiaoming Wang, Jeff Wrana, Malik Slassi, Mark D. Minden, Dwayne L. Barber, Aaron D. Schimmer
Publikováno v:
Oncotarget
Targeting Bruton's tyrosine kinase (BTK) with the small molecule BTK inhibitor ibrutinib has significantly improved patient outcomes in several B-cell malignancies, with minimal toxicity. Given the reported expression and constitutive activation of B
Publikováno v:
Blood. 134:4714-4714
BACKGROUND: Despite advancements in medical therapy and supportive care for sickle cell disease (SCD) over the last several decades, disease morbidity and mortality remain unacceptably high. Allogeneic hematopoietic stem cell transplant (HSCT) is a c
Autor:
Feng-Hsu Lin, Aaron D. Schimmer, Mark D. Minden, Malik Slassi, Jeff Wrana, Dwayne L. Barber, Neil MacLean, Marcela Gronda, Lianne E Rotin, Michael F. Moran, Alessandro Datti
Publikováno v:
Blood. 124:2226-2226
Ibrutinib is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor yielding impressive clinical responses in B-cell malignancies, where BTK contributes to disease development and progression. We noted that BTK is expressed and constitutively ac