Výsledky vyhledávání - "Lianne Beunk"

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics

Autor: Lianne Beunk, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger, Anne-Marie Buunk, Henk Jan Guchelaar, Elisa J. F. Houwink, Arne Risselada, Gerard A. P. J. M. Rongen, Ron H. N. van Schaik, Jesse J. Swen, Daan Touw, Roos van Westrhenen, Vera H. M. Deneer, Jan van der Weide

Publikováno v: European Journal of Human Genetics. Nature Publishing Group
European Journal of Human Genetics. SPRINGERNATURE
European Journal of Human Genetics

The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by developing evidence-based guidelines to optimize pharmacotherapy. A guideline describing the gene-drug interaction between the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d87804d4af6dcbaf1b5d9f3f194979
https://cris.maastrichtuniversity.nl/en/publications/8434c9e0-c985-4bc8-a492-71fb47e9fdc5

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Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype

Autor: Soraya V Ganesh, Pierre M. Bet, Bojan Nikolik, Lianne Beunk, Jan van der Weide

Publikováno v: Therapeutic Drug Monitoring, 43(5), 672-680. Lippincott Williams and Wilkins
Ganesh, S V, Beunk, L, Nikolik, B, van der Weide, J & Bet, P M 2021, ' Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype ', Therapeutic Drug Monitoring, vol. 43, no. 5, pp. 672-680 . https://doi.org/10.1097/FTD.0000000000000868

BACKGROUND: Interpatient variability in cytochrome P450 2D6 (CYP2D6) enzyme activity alters the serum concentrations of most psychotropics, which often have narrow therapeutic indices. Therefore, preemptive knowledge of CYP2D6 activity is desired. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a6f5d353a74c7cbd1d67161f759929
https://doi.org/10.1097/ftd.0000000000000868

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Actomyosin contractility requirements and reciprocal cell–tissue mechanics for cancer cell invasion through collagen-based channels

Autor: Lianne Beunk, Gert-Jan Bakker, Diede van Ens, Jeroen Bugter, Floris Gal, Martin Svoren, Peter Friedl, Katarina Wolf

Publikováno v: European Physical Journal. E. Soft Matter, 45, 5
European Physical Journal. E. Soft Matter, 45

Abstract The interstitial tumor microenvironment is composed of heterogeneously organized collagen-rich porous networks as well as channel-like structures and interfaces which provide both barriers and guidance for invading cells. Tumor cells invadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9569e7f53b5b32a1a64ac9f2a236c57
https://doi.org/10.1140/epje/s10189-022-00182-6

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Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning

Autor: Lianne Beunk, Sjoerd van Helvert, Bram Bekker, Lars Ran, Ross Kang, Tom Paulat, Simon Syga, Andreas Deutsch, Peter Friedl, Katarina Wolf

Metastatic tumor cell invasion into interstitial tissue is a mechanochemical process that responds to tissue cues and further involves proteolytic remodeling of the tumor stroma. How matrix density, tissue guidance and the ability of proteolytic tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab1a961901f0f370645713705a806e19
https://doi.org/10.1101/2022.03.16.484647

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Cancer invasion into musculature: Mechanics, molecules and implications

Autor: Lianne Beunk, Peter Friedl, Iris D. Nagtegaal, Katarina Wolf, Kari Brown

Publikováno v: Semin Cell Dev Biol
Seminars in Cell & Developmental Biology, 93, 36-45
Seminars in Cell & Developmental Biology, 93, pp. 36-45

Contains fulltext : 208467pub.pdf (Publisher’s version ) (Closed access) Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a48c726ee72c26d7feeebfd01e2924e
https://pubmed.ncbi.nlm.nih.gov/30009945

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Role of mast cells in mucosal diseases: current concepts and strategies for treatment

Autor: Lianne Beunk, Anouk Verwoerd, Frans J. van Overveld, Ger T. Rijkers

Publikováno v: Expert review of clinical immunology. 9(1)

Mast cells are well known for their role in type I hypersensitivity. However, their role in the immune system as well as their pathophysiological role in other diseases is underacknowledged. The role of mast cells in inflammatory bowel disease, aller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dcb055287a7da71535667d391f664e
https://pubmed.ncbi.nlm.nih.gov/23256764

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