Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lianne A, Hulshof"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people worldwide. One pathological feature of progressing AD is the loss of synapses. This is the strongest correlate of cognitive decline. Astrocytes, as an essentia
Externí odkaz:
https://doaj.org/article/b559778a0f824ed782c745730e4eddb3
Autor:
Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench‐Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-24 (2020)
Abstract Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regenerati
Externí odkaz:
https://doaj.org/article/774319b15576431a80d815b1901eaee3
Autor:
Lianne A. Hulshof, Leon A. Frajmund, Danny van Nuijs, Denise C.N. van der Heijden, Jinte Middeldorp, Elly M. Hol
Publikováno v:
Neurobiology of Aging. 113:28-38
Alzheimer's disease (AD) is the most common cause of dementia. Despite many years of research, very limited treatment options are available. Here we aim to establish a well-defined learning and memory performance test for an AD mouse model, which can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac47041f0de3ca5374fdd6768df7e90
https://doi.org/10.1016/j.neurobiolaging.2021.12.009
https://doi.org/10.1016/j.neurobiolaging.2021.12.009
Autor:
Tamar Smit, Paul R. Ormel, Jacqueline A. Sluijs, Lianne A. Hulshof, Jinte Middeldorp, Lot D. de Witte, Elly M. Hol, Vanessa Donega
Publikováno v:
Brain, Behavior, and Immunity. 100:219-230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33af40c50c400a1e7f4be1a1647a452
https://doi.org/10.1016/j.bbi.2021.12.001
https://doi.org/10.1016/j.bbi.2021.12.001
Autor:
Christiaan F. M. Huffels, Lana M. Osborn, Lianne A. Hulshof, Lieneke Kooijman, Lukas Henning, Christian Steinhäuser, Elly M. Hol
Publikováno v:
Glia. 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b07d875d21722e729c30319585dee0b
https://doi.org/10.1002/glia.24159
https://doi.org/10.1002/glia.24159
Autor:
Christiaan F. M. Huffels, Lana M. Osborn, Lianne A. Hulshof, Lieneke Kooijman, Lukas Henning, Christian Steinhäuser, Elly M. Hol
Publikováno v:
Glia. 70(4)
Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding amyloid plaques may directly affect neuronal communication, and one of the mechanisms by which astrocytes impact neuronal function is by affecting K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f24ed2471f57e6cc875509b8f194f7b
https://pubmed.ncbi.nlm.nih.gov/34981861
https://pubmed.ncbi.nlm.nih.gov/34981861
Autor:
Lianne A. Hulshof, Nelda Antonovaite, Elly M. Hol, Davide Iannuzzi, Christiaan F. M. Huffels, Wytse J. Wadman
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials, 122:104697. Elsevier BV
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
There is increasing evidence of altered tissue mechanics in neurodegeneration. However, due to difficulties in mechanical testing procedures and the complexity of the brain, there is still little consensus on the role of mechanics in the onset and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a29581287601de28e7d5db308bbd59d
https://research.vu.nl/en/publications/bd06660c-f9fd-4536-bee2-4715ab3b5ed4
https://research.vu.nl/en/publications/bd06660c-f9fd-4536-bee2-4715ab3b5ed4
Autor:
Vanessa Donega, Jacqueline A. Sluijs, Paul R. Ormel, T. Smit, L D de Witte, Elly M. Hol, Jinte Middeldorp, Lianne A. Hulshof
Dysregulation of microglial function contributes to Alzheimer’s disease (AD) pathogenesis. Several genetic and transcriptome studies have revealed microglia specific genetic risk factors, and changes in microglia expression profiles in AD pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2028214f6c6076cc9f807dd46aec2e72
https://doi.org/10.1101/2021.08.12.456055
https://doi.org/10.1101/2021.08.12.456055
Autor:
Tamar, Smit, Paul R, Ormel, Jacqueline A, Sluijs, Lianne A, Hulshof, Jinte, Middeldorp, Lot D, de Witte, Elly M, Hol, Vanessa, Donega
Publikováno v:
Brain, behavior, and immunity. 100
Dysregulation of microglial function contributes to Alzheimer's disease (AD) pathogenesis. Several genetic and transcriptome studies have revealed microglia specific genetic risk factors, and changes in microglia expression profiles in AD pathogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0da8ccd5e0f94dadfe6e3becd3e930d9
https://pubmed.ncbi.nlm.nih.gov/34896594
https://pubmed.ncbi.nlm.nih.gov/34896594
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials, 113:104159. Elsevier
Antonovaite, N, Hulshof, L A, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Viscoelastic mapping of mouse brain tissue : Relation to structure and age ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 113, 104159 . https://doi.org/10.1016/j.jmbbm.2020.104159
Journal of the Mechanical Behavior of Biomedical Materials, 113:104159. Elsevier BV
Antonovaite, N, Hulshof, L A, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Viscoelastic mapping of mouse brain tissue : Relation to structure and age ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 113, 104159 . https://doi.org/10.1016/j.jmbbm.2020.104159
Journal of the Mechanical Behavior of Biomedical Materials, 113:104159. Elsevier BV
There is growing evidence that mechanical factors affect brain functioning. However, brain components responsible for regulating the physiological mechanical environment are not completely understood. To determine the relationship between structure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da079dfed732299d66eeb236779b478
https://doi.org/10.1016/j.jmbbm.2020.104159
https://doi.org/10.1016/j.jmbbm.2020.104159