Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lianhui Tao"'
Autor:
Fadel S. Alyaqoub, Vernon E. Steele, Yue Liu, Lianhui Tao, Ronald A. Lubet, Michael A. Pereira
Publikováno v:
Molecular Carcinogenesis. 47:165-171
Bexarotene has demonstrated chemopreventive and therapeutic efficacy towards mouse lung tumors. Using specimens from our published study that demonstrated the efficacy of bexarotene, we report herein its ability to modulate mRNA expression of genes i
Publikováno v:
Carcinogenesis. 28:1499-1503
CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333 bp polymerase chain reaction product of the estrogen receptor-alpha gene that contained either radiolabeled cytos
Publikováno v:
International Journal of Cancer. 120:1150-1153
Biomarkers are being developed that can aid in the evaluation of cancer therapeutic and chemopreventive drugs. Two suggested biomarkers found in mouse lung tumors are DNA hypomethylation and alterations in mRNA expression of genes, such as 18S RNA, c
Autor:
Vernon E. Steele, Ronald A. Lubet, Paula M. Kramer, William T. Gunning, Lianhui Tao, Michael A. Pereira, Fadel S. Alyaqoub
Publikováno v:
Carcinogenesis. 27:2442-2447
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for modulation of DNA methylation in tumors. Lung tumors were
Publikováno v:
Cancer Letters. 212:145-151
The ability of non-genotoxic colon carcinogens to induce DNA hypomethylation was evaluated. Administering 0, 0.2 and 0.4 mg/kg of 5-aza-2'-deoxycytidine to female mice for 5 days resulted in a dose-related decrease in 5-methylcytosine in colon DNA. R
Autor:
Asad Umar, Yingzhe Li, Wei Wang, Vernon E. Steele, Ronald A. Lubet, Michael A. Pereira, Lianhui Tao
Publikováno v:
Carcinogenesis. 25:1917-1923
The ability of celecoxib and a-difluoromethylornithine(DFMO) to modulate the DNA hypomethylation and thehypermethylation of the estrogen receptor (ER)-a genein colon tumors was evaluated as potential biomarkersfor chemoprevention. Colon tumors were i
Publikováno v:
Toxicology. 196:127-136
Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. DNA hypomethylation is a common molecular event in cancer that is induced by DCA and TCA. Hypomethylation of DNA and the insulin-like growth factor-II (IGF-II) gene
Autor:
Wei Wang, Ronald A. Lubet, Paula M. Kramer, Michael A. Pereira, Vernon E. Steele, Lianhui Tao
Publikováno v:
Molecular Carcinogenesis. 39:79-84
Surrogate end-point biomarkers are being developed as indicators of the efficacy of chemopreventive agents. These biomarkers are molecular and biological end-points that can be modulated by chemopreventive agents in accordance with their efficacy to
Autor:
Michael A. Pereira, Siming Yang, Vernon E. Steele, Wei Wang, Lianhui Tao, Paula M. Kramer, Ronald A. Lubet
Publikováno v:
Carcinogenesis. 23:1447-1454
Modulation of gene expression in tumors has the potential of being a surrogate end-point biomarker for chemoprevention. Thus, we determined the modulation by chemopreventive agents of the protein and mRNA expression of genes in rat colon tumors. Male
Autor:
Eva Szabo, Fadel S. Alyaqoub, Vernon E. Steele, Paula M. Kramer, Ronald A. Lubet, Yingzhe Li, Michael A. Pereira, Lianhui Tao, William T. Gunning
Publikováno v:
Carcinogenesis. 23:1185-1192
Chemopreventive drugs have the potential to decrease the morbidity and mortality of lung cancer. The development of these drugs could be expedited by the application of surrogate end-point biomarkers that demonstrate chemopreventive efficacy. In this